Fig. 10

Drug-drug interaction involved in optimized polytherapy for hypertension, prophylactic therapy for chronic migraine and episodes of acute attacks optimization of previous therapy. From left to right, in the first column there is the list of drug metabolizing enzymes, one for each row, each following column represent a drug the relationship between a drug and an enzyme/transporter is indicated by the symbol ‘S’ for substrate, ‘Inh’ for inhibitor and ‘Ind’ for inducer. The colours of different rows indicate the increase in metabolic pressure passing by the various colours ranging from yellow to orange, to red, to dark red. X = link to related scientific articles about the items in the first column accessible through the related page at the website http://bioinformatics.charite.de/transformer