Fig. 1
From: The need for new acutely acting antimigraine drugs: moving safely outside acute medication overuse
Schematic representation of potential receptor expression changes upon chronic drug use. Receptor expression in the cell membrane in healthy condition (a), after prolonged agonist exposure (b), and after prolonged antagonist exposure (c). After prolonged agonist exposure, downregulation and desensitization (by arrestin binding after phosphorylation by GPCR Kinase) could occur. After prolonged antagonist exposure, receptor upregulation is expected to take place