CALCA and TRPV1 genes polymorphisms are related to a good outcome in female chronic migraine patients treated with OnabotulinumtoxinA

Table 2 Association between response to OnabotA and SNP rs3781719 in the gene CALCA

						P value				Odds ratio (95% CI)
POPULATION	RESPONSE	GENOTYPES			MINOR ALLELE FREQUENCY (%)	GENOTYPIC FREQUENCY	ALLELE FREQUENCY	ALLELE C RECESIVITY HYPOTHESIS	ALLELE C DOMINANCE HYPOTHESIS	Dominant model	Codominant model	Recessive model
POPULATION	RESPONSE	TT	TC	CC	MINOR ALLELE FREQUENCY (%)	GENOTYPIC FREQUENCY	ALLELE FREQUENCY	ALLELE C RECESIVITY HYPOTHESIS	ALLELE C DOMINANCE HYPOTHESIS	Dominant model	Codominant model	Recessive model
n = 150	Responders (n = 117)	63	45	9	26,9	0.023	0.029	0.794	0.007	3,11 (1,33-7,26)	1,6 (0,85-3,0)	1,2 (0,31-4,71)
n = 150	Non-responders (n = 33)	9	21	3	40,9	0.023	0.029	0.794	0.007	3,11 (1,33-7,26)	1,6 (0,85-3,0)	1,2 (0,31-4,71)

ISSN: 1129-2377