Fig. 1

Schematic and incomplete drawing of hypothalmic and cerebellar pathways involved in the modulation of migraine and probably also of periodic syndromes [136, 155, 162, 163, 167,168,169,170]. The pathways are not differentiated in excitatory or functionally inhibitory pathways (e.g. the vagal connections to the spinal trigeminal nucleus are functionally inhibitory as it is also shown for the cerebellar pathways to the vestibular nucleus). green = hypothalamus, yellow = thalamus, grey = cerebellum; green = vestibular complex, blue = sensory trigeminal nucleus, pink = area postrema, rose = nucleus ambiguous (as part of the vagal complex)