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Fig. 2 | The Journal of Headache and Pain

Fig. 2

From: Histamine and migraine revisited: mechanisms and possible drug targets

Fig. 2

Neuronal H3 receptors are located on both histaminergic (brown) and non-histaminergic neurons (arrows). On histaminergic neurons H3 acts as an autoreceptor inhibiting the release of histamine itself. The figure shows the complex distribution of H3 receptors that emphasizes the challenge of predicting the effects mediated by H3 receptors. Reprinted from (12) Copyright© 2015 with permission from ASPET, Pharmacol Rev.

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