Relationship between changes in resting-state spontaneous brain activity and cognitive impairment in patients with CADASIL

Table 2 Significant inter-group differences in ALFF among CADASIL and controls

Predominant regions in cluster	Cluster size	Peak T value	MNI coordinates			Cluster level P_FWE-corr
			x	y	z
ALFF reduction in CADASIL
Right Pcu/CU (BA 7/BA 17)	210	−5.31	6	− 81	30	0.000
ALFF increase in CADASIL
Left SFG (BA 10)	88	5.28	−12	60	3	0.008
Right SFG (BA 10)	62	4.82	21	60	− 6	0.034
Left cerebellar anterior and posterior lobes	58	4.38	−9	− 51	− 36	0.044

The surviving clusters of ALFF were assigned thresholds of p < 0.001 and FWE-corrected to p < 0.05 at the cluster level
ALFF amplitude of low-frequency fluctuation, CADASIL cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, Pcu/CU precuneus and cuneus, SFG superior frontal gyrus, BA Brodmann’s area, MNI Montreal Neurological Institute

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