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Table 2 Significant inter-group differences in ALFF among CADASIL and controls

From: Relationship between changes in resting-state spontaneous brain activity and cognitive impairment in patients with CADASIL

Predominant regions in cluster Cluster size Peak T value MNI coordinates Cluster level PFWE-corr
    x y z  
ALFF reduction in CADASIL
 Right Pcu/CU (BA 7/BA 17) 210 −5.31 6 − 81 30 0.000
ALFF increase in CADASIL
 Left SFG (BA 10) 88 5.28 −12 60 3 0.008
 Right SFG (BA 10) 62 4.82 21 60 − 6 0.034
 Left cerebellar anterior and posterior lobes 58 4.38 −9 − 51 − 36 0.044
  1. The surviving clusters of ALFF were assigned thresholds of p < 0.001 and FWE-corrected to p < 0.05 at the cluster level
  2. ALFF amplitude of low-frequency fluctuation, CADASIL cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, Pcu/CU precuneus and cuneus, SFG superior frontal gyrus, BA Brodmann’s area, MNI Montreal Neurological Institute
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