Fig. 7
From: ROS/TRPA1/CGRP signaling mediates cortical spreading depression
A diagram depicting ROS/TRPA1/CGRP signaling in modulating cortical susceptibility to CSD. It is proposed that ROS may trigger TRPA1 activation and CGRP production, which create a positive feedback loop in regulating cortical susceptibility to CSD. In which way, ROS could facilitate CSD propagation for the subsequent development of migraine