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Table 1 Summary of studies dealing with gangliolysis techniques and gamma knife radiosurgery in patients with multiple sclerosis-related trigeminal neuralgia

From: Trigeminal neuralgia secondary to multiple sclerosis: from the clinical picture to the treatment options

Gasserian ganglion percutaneous techniques
Author Procedure no Complete pain relief* (%) Mean follow-up (months) Complication rate (%) Recurrence rate (%)
Broggi, 1982 Radiofrequency rhizotomy 14 100 NA NA 40
Hooge and Redekop, 1995 Radiofrequency rhizotomy 17 57 72 NA 43
Kanpolat, 2000 Radiofrequency rhizotomy 17 70,6 60 76,5 29,4
Berk, 2003 Radiofrequency rhizotomy 13 81 52 0 50
Mallory, 2012 Radiofrequency rhizotomy 67 40 28.3 3 54
Holland, 2017 Radiofrequency rhizotomy 10 71 66 66 60
Dieckmann, 1987** Glycerol rhizotomy 21 NA NA NA 40
Kondziolka, 1994 Glycerol rhizotomy 53 60 36 0 40
Pickett, 2005 Glycerol rhizotomy 53 78 81 20 59
Mathieu, 2012 Glycerol rhizotomy 18 100 38 66,7 38.9
Mohammad-Mohammadi, 2013 Glycerol rhizotomy 39 74 68,4 3 69
Kouzounias, 2010 Balloon compression 17 88 20 0 70,5
Mallory, 2012 Balloon compression 69 26 17.8 17.4 64
Montano, 2012 Balloon compression 21 81 51,5 0 57
Mohammad-Mohammadi, 2013 Balloon compression 19 95 68,4 5 61
Bergenheim, 2013** Balloon compression 23 NA NA NA NA
Martin, 2015 Balloon compression 17 82 43 21 86
Alvarez-Pinzon, 2016 Balloon compression 78 87 18 21 NA
Rogers, 2002 Stereotactic radiosurgery 15 80 17 13 33.3
Zorro, 2009 Stereotactic radiosurgery 37 62.1 56.7 5.4 37.8
Verheul, 2010 Stereotactic radiosurgery 13 90 16 37 35
Mathieu, 2012 Stereotactic radiosurgery 27 89 39 22.2 51.9
Weller, 2014 Stereotactic radiosurgery 35 35 39 39 40.7
Tuleasca, 2014 Stereotactic radiosurgery 43 90.7 53.8 16 61.5
Alvarez-Pinzon, 2016 Stereotactic radiosurgery 124 23 24 10 NA
Holland, 2017 Stereotactic radiosurgery 7 71 10 60 29
Conti, 2017 Stereotactic radiosurgery 27 85 37 26 56
Colin, 2018 Stereotactic radiosurgery 42 62 78 10 87
Broggi et al., 2004 Microvascular decompression 35 39 44 NA NA
Athanasiou et al., 2005 Microvascular decompression 5 100 38.8 0 20
Eldridge et al., 2003 Microvascular decompression 9 100 12 11 66
Sandell T and Eide, 2010 Microvascular decompression 15 47 65 33 NA
Ariai et al., 2014 Microvascular decompression 10 80 14 10 60
  1. NA not available
  2. *Pain relief with no need of pharmacological treatment
  3. **These studies investigated patients with classical and MS-related TN and does not provide distinct data of the two conditions