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Fig. 2 | The Journal of Headache and Pain

Fig. 2

From: Trigeminal neuralgia secondary to multiple sclerosis: from the clinical picture to the treatment options

Fig. 2

Voxel-based analysis in patients with TN secondary to MS. Voxel-based brainstem model in patients with TN secondary to MS (TN group, n = 42) and in patients with trigeminal sensory disturbances due to MS (non-TN group, n = 29). The statistical analysis in patients with TN secondary to MS showed an area of very high probability of a lesion (P < 0.0001) centred in the ventrolateral pons between the trigeminal root entry zone and the trigeminal nuclei, i.e. along the intrapontine part of the trigeminal primary afferents. In the non-TN group, the area of high probability of lesion (P < 0.001) corresponded to a more caudal, medial, and dorsal pontine region involving the subnucleus oralis of the spinal trigeminal complex. The axial sections in this figure correspond to the sections 120 and 160 of the Shaltenbrandt atlas. The level of probability is colour-coded. Blue indicates non-significant areas, white the minimum level of significance (P < 0.05), and red the highest level of significance. Reproduced from [15]

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