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Table 3 Synthesis of results

From: The effect of aerobic exercise on the number of migraine days, duration and pain intensity in migraine: a systematic literature review and meta-analysis

Study ID Patients Intervention Intensity Control FU Results Confounding
Bond 2018 [24] N = 54
MWA/O, ICHD-III
≥ 3 attacks/m
4–20 migraine d/m (3m)
16w BWL program
250min./w
5x/w home-based
Moderate N = 56
Migraine education
Self-management
4m Number of migraine days: /
Pain intensity: + 20%
Attack duration: + 23%
All results: NSa
Overweight or obese (BMI = 25–49.9 kg/m2)
Preventive/abortive pharmacological treatment if stable regimen ≥2m
Darabaneanu 2011 [25] N = 8
MWA/O, ICHD-II
≥ 2 attacks/m
Prior:
No aerobic training
10w jogging
50min.
3x/w supervised
1/3 @ home
60–75%
VO2peak
N = 8
No intervention
8w Number of migraine days: − 39%
Pain intensity: − 20%
Attack duration: − 20%
Dropout 50%
Hanssen 2017 [26] N = 30
I1 = 15 (HIT)
I2 = 15 (MCT)
EM without aura, ICHD-IIIb
Prior:
No regular exercise
No prophylaxis 8w
12w HIT (4 times)
2x/w 4min. 90%
3min. rest 70%
12w MCT, 2x/w 45min.
2x/w supervised
HIT:
90–95% HR
MCT:
70% HR
N = 15
Maintain daily physical activity and physical activity recommendations
/ Number of migraine days:
−29% (MCT)
− 63% (HIT)
Pain intensity: /
Attack duration: /
All results: NSa
 
Krøll 2018 [29] N = 36
EM and CM combined with NP and TTH, ICHD-IIIb
≥ 2 attacks/m
3m cycling/cross-training/brisk walking/running
3x/w 45min.
1x/w supervised
2/3 @ home/gym
RPE scale 14–16 N = 36
Maintain daily physical activity
3m Number of migraine days: −22%
Pain intensity: − 20%
Attack duration: − 23%
Participants engaged in some form of exercise activity could continue. Preventive and acute medication allowed.
Santiago 2014 [27] N = 24
CM, ICHD-II
Prior:
No exercise for 3m
No prophylaxis
12w fast walking + amitriptyline (25mg/d)
3x/w 40min.
supervised weekly by telephone
Aerobic
(HR + Borg)
N = 26
25mg/d amitriptyline
12w Number of migraine days: − 78%
Pain intensity: − 54%
Attack duration: − 27%
Amitriptyline use (TCA)
Varkey 2011 [28] N = 16
MWA/O, ICHD-II
2–8 attacks/m
> 1y migraine
b before age of 50
Prior:
< 1x/w exercise 12w
12w indoor cycling
3x/w 40min. supervised
≥ 2/3 @home
RPE scale
14–16
N = 31
Relaxation (N = 14)
5-20min./w
Topiramate (N = 17)
25mg/w - 200mg/d
10-12m Number of migraine days: −28%
Pain intensity: − 18%
Attack duration: /
All results: NSa
50% of all ITT patients have 6m FU
  1. Legend: a between-group differences, b onset, BWL behavioral weight loss program, C control group, CM chronic migraine, d day(s), FU follow-up, HIT high-intensity interval training, HR heartrate, I intervention, ICHD international classification of headache disorders, ITT intention-to-treat analysis, m month(s), MCT moderate continuous aerobic training, MWA/O migraine with/without aura, N number of, NP neck pain, NS non-significant, PP per-protocol analysis, RPE rate of perceived exertion, TCA tricyclic antidepressant, TTH tension-type headache, w week(s)