Outcomes | Anticipated absolute effects (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
---|---|---|---|---|---|---|
Risk with placebo | Risk with erenumab | |||||
Reduction of monthly migraine days follow up: 3 months | The mean reduction of monthly migraine days was −4.2 days | The mean reduction of monthly migraine days in the intervention group was 2.5 days fewer (3.5 fewer to 1.4 fewer) | – | 468 (1 RCT) | ⨁⨁⨁◯ MEDIUMa | Treatment with Erenumab 140 mg reduces monthly migraine days slightly compared to placebo. |
Reduction of monthly acute treatment days follow up: 3 months | The mean reduction of monthly acute treatment days was −1.6 days | The mean reduction of monthly acute treatment days in the intervention group was 2.6 days fewer (3.3 fewer to 1.8 fewer) | – | 468 (1 RCT) | ⨁⨁⨁◯ MEDIUMa | Treatment with Erenumab 140 mg reduces monthly acute treatment days slightly compared to placebo. |
At least 50% reduction of monthly migraine days follow up: 3 months | 235 per 1000 | 412 per 1000 (314 to 540) | RR 1.7531 (1.3359 to 2.3007) | 468 (1 RCT) | ⨁⨁⨁◯ MEDIUMa | Treatment with Erenumab 140 mg results in at least 50% reduction of monthly migraine days compared to placebo. |
Serious adverse events follow up: 3 months | 25 per 1000 | 11 per 1000 (2 to 51) | RR 0.4286 (0.0900 to 2.0408) | 470 (1 RCT) | ⨁⨁⨁◯ MEDIUMa | Treatment with Erenumab 140 mg results in a small unimportant increase of serious adverse event occurrence compared to placebo. |
Mortality follow up: 3 months | 0 per 1000 | 0 per 1000 (0 to 0) | not estimable | 470 (1 RCT) | No deaths were observed with treatment with Erenumab 140 mg or placebo |