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Table 3 Model-estimated proportion of patients with episodic and chronic migraine with maintained response

From: Preventive effects of galcanezumab in adult patients with episodic or chronic migraine are persistent: data from the phase 3, randomized, double-blind, placebo-controlled EVOLVE-1, EVOLVE-2, and REGAIN studies

Response rate

Galcanezumab 120 mg

(N = 436)

Galcanezumab 240 mg

(N = 428)

Placebo

(N = 875)

Episodic migrainea

 75% Response ≥3 consecutive monthsb

19.7%

21.3%

8.5%

  Odds ratio (95% CI)

2.7 (1.9, 3.7)*

2.9 (2.1, 4.1)*

 75% Response all 6 months

6.2%

6.8%

1.8%

  Odds ratio (95% CI)

3.5 (1.9, 6.3)*

3.9 (2.1, 6.9)*

 100% Response ≥3 consecutive monthsb

3.7%

6.5%

2.7%

  Odds ratio (95% CI)

1.4 (0.7, 2.5)

2.5 (1.4, 4.2)*

 100% Response all 6 months

0.7%

1.4%

0.2%

  Odds ratio (95% CI)

2.9 (0.8, 10.4)

5.3 (1.6, 17.1)

Chronic migrainec

Galcanezumab 120 mg

(N = 273)

Galcanezumab 240 mg

(N = 274)

Placebo

(N = 538)

 30% Response all 3 months

29.3%

29.2%

16.4%

  Odds ratio (95% CI)

2.1 (1.5, 3.0)*

2.1 (1.5, 3.1)*

 75% Response all 3 months

2.6%

2.9%

2.0%

  Odds ratio (95% CI)

1.3 (0.6, 3.1)

1.5 (0.6, 3.4)

  1. Abbreviations: CI confidence interval
  2. a6-month study
  3. bMaintained response until patient’s endpoint of the 6-month, double-blind period
  4. c3-month study
  5. *p < 0.001 versus placebo
  6. p = 0.006 versus placebo