Fig. 1

Mean monthly number of migraine attacks and their intensity recorded on the headache diary in the 3 treatment groups (flunarizine; flunarizine + bupivacaine injection of the TrP, flunarizine + 3% nimesulide gel application over the TrP)(n. 25 patients each, Means ± SD) in basal conditions (1 month preceding start of treatment) and 30, 60 and 180 days from start of treatment. * = p < 0.05; ** = p < 0.01; *** = p < 0.001: comparison of treatment and post-treatment evaluations with basal values