TY - JOUR AU - Grazzi, Licia AU - Tassorelli, Cristina AU - de Tommaso, Marina AU - Pierangeli, Giulia AU - Martelletti, Paolo AU - Rainero, Innocenzo AU - Geppetti, Pierangelo AU - Ambrosini, Anna AU - Sarchielli, Paola AU - Liebler, Eric AU - Barbanti, Piero AU - Tassorelli, Cristina AU - Bitetto, Vito AU - De Icco, Roberto AU - Martinelli, Daniele AU - Sances, Grazia AU - Bianchi, Monica AU - Grazzi, Licia AU - Padovan, Anna Maria AU - de Tommaso, Marina AU - Ricci, Katia AU - Vecchio, Eleonora AU - Cortelli, Pietro AU - Cevoli, Sabina AU - Pierangeli, Giulia AU - Terlizzi, Rossana AU - Martelletti, Paolo AU - Negro, Andrea AU - Chiariello, Gabriella Addolorata AU - Rainero, Innocenzo AU - De Martino, Paola AU - Gai, Annalisa AU - Govone, Flora AU - Masuzzo, Federica AU - Rubino, Elisa AU - Torrieri, Maria Claudia AU - Vacca, Alessandro AU - Geppetti, Pierangelo AU - Chiarugi, Alberto AU - De Cesaris, Francesco AU - Puma, Simone Li AU - Lupi, Chiara AU - Marone, Ilaria AU - Ambrosini, Anna AU - Perrotta, Armando AU - Sarchielli, Paola AU - Bernetti, Laura AU - Corbelli, Ilenia AU - Romoli, Michele AU - Simoni, Simone AU - Verzina, Angela AU - Barbanti, Piero AU - Aurilia, Cinzia AU - Egeo, Gabriella AU - Fofi, Luisa AU - Liebler, Eric AU - Andersson, Annelie AU - Spitzer, Lia AU - Marin, Juana AU - McClure, Candace AU - Thackeray, Lisa AU - Baldi, Maria Giovanna AU - Di Maro, Daniela AU - on Behalf of the PRESTO Study Group PY - 2018 DA - 2018/10/19 TI - Practical and clinical utility of non-invasive vagus nerve stimulation (nVNS) for the acute treatment of migraine: a post hoc analysis of the randomized, sham-controlled, double-blind PRESTO trial JO - The Journal of Headache and Pain SP - 98 VL - 19 IS - 1 AB - The PRESTO study of non-invasive vagus nerve stimulation (nVNS; gammaCore®) featured key primary and secondary end points recommended by the International Headache Society to provide Class I evidence that for patients with an episodic migraine, nVNS significantly increases the probability of having mild pain or being pain-free 2 h post stimulation. Here, we examined additional data from PRESTO to provide further insights into the practical utility of nVNS by evaluating its ability to consistently deliver clinically meaningful improvements in pain intensity while reducing the need for rescue medication. SN - 1129-2377 UR - https://doi.org/10.1186/s10194-018-0928-1 DO - 10.1186/s10194-018-0928-1 ID - Grazzi2018 ER -