Studies (participants) | Outcome | Comparison | Type | Quality | Effect size | GRADE quality of evidence | Direction | Strength | Comment |
---|---|---|---|---|---|---|---|---|---|
Dodick (1384) | Headache days | OnabotA 155 U–195 U versus placebo | R | −1 | 0 | Moderate | For | Strong | Quality points deducted for risk of bias (−1) |
Diener (2436) | Adverse events | OnabotA 75 U–260 U versus placebo | R | -1 | + 1 | High | For | Strong | Quality points deducted for risk of bias (−1). Effect size point added for small frequency of AE |