Table 3 Longitudinal changes in all efficacy variables from baseline (T0 - trimester before initiation of therapy) over three years of onabotulinumtoxinA (Botox ®) (T3) in 56 patients

Headache days/month

21.5 ± 5.1

14–30

20

7.2 ± 3.8

2–15

6

5.4 ± 2.6

1–11

5

3.4 ± 1.7

1–11

4

^*P < 0.001

^**P < 0.001

Number of days with peak headache intensity of more than 4/10 per month

11.7 ± 5.7

4–30

10

3.4 ± 2.8

0–14

3

3.2 ± 1.6

1–7

3

2.5 ± 1.1

1–5

2

^*P = 0.052

^**P < 0.001

Days with any acute headache medication / month

16.5 ± 7.3

7–30

14

4.7 ± 3.2

0–14

4

3.4 ± 1.7

1–8

3

2.8 ± 1.3

1–7

2

^*P < 0.001

^**P < 0.001