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Table 3 Clinical similarities and differences amongst cluster headache, migraine without aura and migraine with aura

From: Migraine and cluster headache – the common link

Headache phenotype Cluster Headache Migraine without aura Migraine with aura  
Location Strictly unilateral Usually unilateral Similarities
Intensity Severe/very severe Moderate/severe
Associated symptoms Nausea, photophobia and phonophobia
Aura (≈20%) [103] - Aura
Quality Excruciating, stabbing Deep, pulsating Differences
Duration 15-180 minutes 4-72 hours
Radiation Orbital, supraorbital and/or temporal Frontotemporal
Circadian/circannual rhythms Nocturnal [22]
Early morning [108]-
Frequency Once every other day to eight times a day Once every other day
Most common triggers Alcohol [5] Stress, cycling female hormones [239], [113] (but also alcohol)
Aggravators - Routine physical activity
Cranial autonomic symptoms Ipsilateral, prominent Bilateral, mild [66]
Disability during headache Restlessness or agitation Severe impairment or require bed rest