TY - JOUR AU - Vollesen, Anne Luise AU - Benemei, Silvia AU - Cortese, Francesca AU - Labastida-Ramírez, Alejandro AU - Marchese, Francesca AU - Pellesi, Lanfranco AU - Romoli, Michele AU - Ashina, Messoud AU - Lampl, Christian AU - on behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS) PY - 2018 DA - 2018/09/21 TI - Migraine and cluster headache – the common link JO - The Journal of Headache and Pain SP - 89 VL - 19 IS - 1 AB - Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. Recent data also suggest efficacy of anti CGRP monoclonal antibodies in both migraine and cluster headache. While exact mechanisms behind both disorders remain to be fully understood, the trigeminovascular system represents one possible common pathophysiological pathway and network of both disorders. Here, we review past and current literature shedding light on similarities and differences in phenotype, heritability, pathophysiology, imaging findings and treatment options of migraine and cluster headache. A continued focus on their shared pathophysiological pathways may be important in paving future treatment avenues that could benefit both migraine and cluster headache patients. SN - 1129-2377 UR - https://doi.org/10.1186/s10194-018-0909-4 DO - 10.1186/s10194-018-0909-4 ID - Vollesen2018 ER -