From: Aids to management of headache disorders in primary care (2nd edition)
First line: • Amitriptyline or nortriptyline, 10–100 mg at night | • Intolerance is reduced by starting at a low dose (10 mg) and incrementing by 10–25 mg every 1–2 weeks; • Nortriptyline has fewer anticholinergic side-effects but less good evidence of efficacy |
Second line (either as monotherapy or as add-on medication): • Gabapentin 600–3600 mg daily • Pregabalin 150–600 mg daily |