Fig. 1
From: PACAP38 and PAC1 receptor blockade: a new target for headache?
PACAP receptors. Three receptors to PACAP have been described: VPAC1, VPAC2 and PAC1. VIP and PACAP show similar affinity for VPAC1 and VPAC2, whereas PACAP is 100-fold more selective for PAC1 receptor. The antibodies developed for prophylactic antimigraine treatment bind either to PACAP (PACAP38, ALD1910) or to the PAC1 receptor (AMG 301)