Exploration of intrinsic brain activity in migraine with and without comorbid depression

Table 1 Demographic and clinical characteristics of all subjects

	dMIG (n = 10)	ndMIG (n = 22)	MDD (n = 13)	HC (n = 27)	P value
Age, y, mean (SD)	27.8 (9.25)	33.59 (8.07)	30.92 (9.1)	29.48 (7,18)	0.206^a
Male	3 (30%)	5 (22.7%)	3 (23%)	10 (37%)	0.685^b
Education, y, mean (SD)	13.6 (3.41)	19 (3.28)	13.65 (2.93)	16.11 (3.02)	0.531^a
Clinical characters of migraine
With/without aura	0/10	0/22	NA	NA
Duration of migraine, y, mean (SD)	7.2 (5.55)	9.82 (7.14)	NA	NA	0.314^c
Attack frequency, per month, mean (SD)	8.52 (7.02)	4.5 (3.50)	NA	NA	0.08^c
Attack duration, h, mean (SD)	18.65 (14.39)	12.75 (16.79)	NA	NA	0.42^c
VAS score (0–10), mean (SD)	6.55 (1.17)	5.88 (1.31)	NA	NA	0.174^c
HIT-6, mean (SD)	65.1 (6.26)	60 (5.77)	NA	NA	0.081^c
MoCA, mean (SD)	27.5 (2.88)	27.82 (1.5)	27.92 (1.66)	30.59 (1.83)	0.620^a
24-HRSD, mean (SD)	26.9 (6.67)	3 (2.23)	27.85 (6.49)	2.48 (2.12)	< 0.001^{a d}
14-HAMA, mean (SD)	6 (1.826)	3.82 (2.59)	5.23 (2.28)	4.19 (2.69)	0.088^a

^aP value for the age, MoCA and neuropsychological scores distribution in the four groups were obtained using a separate one-way ANCOVA tests. Post-hoc tests were then performed using the t-test
^bP value for the gender distribution and sleep disturbance in the four groups were obtained using a chi-squared test
^cP value for the clinical characters distribution for dMIG and ndMIG group were obtained using two sample t-test
^dPost-hoc paired comparisons showed significant differences between dMIG versus ndMIG and HC, depression versus ndMIG and HC, P < 0.001
dMIG migraine with depression, ndMIG migraine without depression group, MDD major depressive disorder, HC health control group, VAS visual analogue scale, HIT-6 Headache Impact Test, MoCA Montreal Cognitive Assessment, 24-HRSD 24-Hamilton Rating Scale for Depression, 14-HAMA Hamilton Anxiety Rating Scale Values are represented as the mean (standard deviation)

ISSN: 1129-2377