Fig. 1
From: Medication-overuse headache: a widely recognized entity amidst ongoing debate
Current understanding of the pathophysiology of medication-overuse headache (MOH). The knowledge on the pathophysiology of MOH involves conversion from and reversion to primary headache disorders, showing changes in physiological processes, functional connectivity and structural changes of the central nervous system, in patients with underlying genetic susceptibility. Abbreviations: MOH: medication-overuse headache; CNS: central nervous system