Table 2 Values of diastolic blood pressure and heart rate during the infusion of methoxamine (20 μg/kg·min): (i) before; (ii) immediately after (within 0–1 min after antagonist administration); and (iii) 10 min after i.v. administration of saline, rauwolscine, GR127935 and haloperidol given separately, as well as their respective combinations
Treatment | Dose (μg/kg) | n | Diastolic blood pressure (mm Hg) | Heart rate (beats per min) | ||||
|---|---|---|---|---|---|---|---|---|
Before | 0–1 min after | 10 min after | Before | 0–1 min after | 10 min after | |||
Saline | 1a | 5 | 155 ± 9 | 158 ± 7 | 160 ± 13 | 260 ± 6 | 267 ± 3 | 259 ± 6 |
Rauwolscine (Rauw) | 310 | 5 | 131 ± 5 | 105 ± 15* | 134 ± 6 | 261 ± 6 | 257 ± 6 | 264 ± 5 |
GR127935 (GR) | 31 | 5 | 137 ± 6 | 134 ± 7 | 140 ± 11 | 257 ± 4 | 251 ± 5 | 250 ± 5 |
Haloperidol (Halo) | 310 | 5 | 124 ± 7 | 67 ± 4* | 119 ± 7 | 234 ± 3 | 229 ± 3 | 230 ± 4 |
Rauw+GR | 310, 31 | 5 | 168 ± 15 | 116 ± 13* | 163 ± 11 | 264 ± 7 | 255 ± 8 | 271 ± 6 |
GR+ Halo | 31, 310 | 5 | 149 ± 10 | 92 ± 15 | 119 ± 7 | 270 ± 10 | 259 ± 7 | 268 ± 9 |
Rauw+Halo | 310, 310 | 5 | 123 ± 7 | 84 ± 6* | 110 ± 3 | 298 ± 1 | 283 ± 3 | 300 ± 10 |