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Fig. 2 | The Journal of Headache and Pain

Fig. 2

From: Dihydroergotamine inhibits the vasodepressor sensory CGRPergic outflow by prejunctional activation of α2-adrenoceptors and 5-HT1 receptors

Fig. 2

Effect of i.v. bolus injections of: (a) saline (1 ml/kg); (b) rauwolscine (310 μg/kg); (c) GR127935 (31 μg/kg); or (d) haloperidol (310 μg/kg) given separately, as well as the combinations (e) rauwolscine plus GR127935 (310 and 31 μg/kg, respectively); (f) rauwolscine plus haloperidol (310 μg/kg each); or (g) GR127935 plus haloperidol (31 and 310 μg/kg, respectively) on the inhibition induced by dihydroergotamine (DHE; 3.1 μg/kg·min; □) of the electrically-induced vasodepressor responses. The control responses () represent that of animals receiving an i.v. continuous infusion of methoxamine (20 μg/kg·min) which is shown for comparison. * Significantly different responses (P < 0.05) vs. control

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