Skip to main content
Fig. 4 | The Journal of Headache and Pain

Fig. 4

From: Characterization of the trigeminovascular actions of several adenosine A2A receptor antagonists in an in vivo rat model of migraine

Fig. 4

Effect of i.v. CGS21680 on the dural diameter. CGS21680 (10 μg/kg) was injected followed by an injection of vehicle and varying doses of JNJ-39928122 (a), n = 5, Dunnet critical value: 1014), JNJ-40529749 (b), n = 3–5, Dunnet critical value: 3791) JNJ-41942914 (c), n = 4, Dunnet critical value: 6008), JNJ-40064440 (d), n = 3–4, Dunnet critical value: 8446), or JNJ-41501798 (e), n = 5–6, Dunnet critical value: 5848). Data are presented as percentage of increase in diameter (left panels) and changes in mean arterial blood pressure (mm Hg, right panels) induced by CGS21680 (left lower panels). CGS, 10 μg/kg CGS21680 i.v.; * p < 0.05, ** p < 0.01, *** p < 0.001 compared to the vehicle. #CGS in presence of vehicle. Open circles represent baseline measurements before injections. JNJ-40064440 was dissolved in water, so vehicle measurements equal control

Back to article page