Fig. 3
Effect of A2A antagonists on perivascular electrical stimulation of the dural artery. Perivascular electrical stimulation (150–250 μA) in the absence or presence of vehicle, or varying doses of JNJ-39928122 (A, n = 4), JNJ-40529749 (B, n = 4–5), JNJ-41942914 (C, n = 6), JNJ-40064440 (D, n = 4), or JNJ-41501798 (E, n = 7–8). Data are presented as percentage of increase in diameter, left panels) and changes in mean arterial blood pressure (mm Hg, right panels) induced by periarterial electrical stimulation (ES). Note that none of the treatments produced any significant changes (p > 0.05 compared to the vehicle). Open circles represent baseline measurements before injections/ES. JNJ-40064440 was dissolved in water, so vehicle measurements equal control