GrƤnde, 2013 [8] | Investigate effect of PACAP27 and PACAP38 on human and rat arteries. | In vitro myograph of human MCA and in vitro pressurized arteriography of rat MCA. | PACAP38 and PACAP27 had effect after abluminal but not luminal application in the rat. Both PACAPs had effect on the human MCA abluminal. | Luminal application of PACAP to the human MCA was not done in this study. |
Amin, 2012 [4] | Investigate effect of i.v. PACAP38 infusion on MCA and MMA in healthy volunteers. | MR-angiography before and after iv infusion of PACAP38. | Large dilation of the MMA but no change of the MCA caliber. | MMA dilation was long-lasting (110Ā min), while MCA remained unchanged. |
Amin, 2014 [5] | Investigate effect of i.v. PACAP38 infusion on MCA and MMA in migraine patients. | MR-angiography before and after iv infusion of PACAP38. | Large dilation of the MMA but no change of the MCA caliber. | MMA dilation was long-lasting (120Ā min), while MCA remained unchanged. Median time from infusion start to onset of migraine was 4.5Ā h. |