Table 3 The criteria for endophenotypes (adapted from Gottesman et al. [17])
1 | The endophenotype is associated with illness in the population |
2 | The endophenotype is heritable |
3 | The endophenotype is primarily state independent (manifests in an individual whether or not illness is active) |
4 | Within families, the endophenotype and illness co-segregate |
5 | The endophenotype found in affected family members are found in non-affected family members at a higher rate than in the general population |