Table 1 Prediction of case control status using Polygenic Risk Score

Ruderfer et al. [51]

2794 cases (SCZ) and 2976 controls

334 cases (SCZ) and 360 controls

Variance explained by SCZ PRS was 5%. The PRS was higher in cases than controls. Population stratification did not influence the outcome.

Chang et al. [52]

6989 cases (NHS)

3 of the 4 NHS-GWAS [53] sub-studies were used as training sets

PRS was estimated by 3 different approaches: internal whole-genome scoring and two external PRS weighting algorithms from independent samples. The 3 PRS approaches explained 0.2% of the variance in depressive symptoms.

Kauppi et al. [20]

9146 cases (SCZ) and 12,111 controls

63 cases (SCZ) and 118 controls

PRS was significantly higher in patients than controls, and a higher PRS was associated with dysfunction of frontal lobe activation during work-memory related tasks.