Fig. 1
AVENGEME [7] was used to calculate the study power (y-axis) given different target sample sizes (x-axis) for migraine. For the calculation we used assumptions derived from Gormley et al.: Discovery cohort = 375.000; variance explained in the discovery sample = 0.1463; and a prevalence of 0.158. Further, we assumed that the fraction of NULL SNPs is 0.95 and that the outcome is binary. The effects from Gormley et al. are used to weigh the SNPs for calculating the PRS. We present six curves representing two different prevalences of migraine in the target sample (circle = 0.2 and triangle = 0.5) given three different PT in the discovery sample (black = 5 × 10− 8, red = 1 × 10− 4, and blue = 0.05