Fig. 2

Drug-drug interactions between preventative and acute migraine medications. The reported classes of drugs compete for the same metabolic pathway, and this represents the most common causes of drug reduction of efficacy and/or toxicity (for details please refer to ref. [23], specifically to tables 1 and 2), leading to medication overuse. Legenda AINS: anti-inflammatory non-steroidal drugs; CYP450: cytochromes P450 (accounting for the metabolism of more than 70% of prescribed drugs); MAOA: monoaminoxidase-A