Table 1 Data on relaxant responses induced by PACAP1–38, PACAP1–27 and VIP performed in vitro on cerebral arteries from different species
From: PACAP and its receptors in cranial arteries and mast cells
Species | PACAP1–38 | PACAP1–27 | VIP | Reference | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
pD2 | Emax | n | pD2 | Emax | n | pD2 | Emax | n | ||
Cat | 7.9 ± 0.2 | 24 ± 9 | 7 | 7.7 ± 0.4 | 31 ± 5 | 7 | 8.3 ± 0.1 | 68 ± 8 | 8 | Jansen-Olesen et al. 1994 [46] |
Rabbit | n.d. | n.d. | – | 8.0 ± 0.1 | 53 ± 11 | 6 | 8.1 ± 0.1 | 73 ± 5 | 6 | Dalsgaard et al. 2003a [23] |
Rat | 7.8 ± 0.1 | 48 ± 7 | 8 | 8.0 ± 0.1 | 51 ± 3 | 8 | 8.0 ± 0.2 | 52 ± 8 | 7 | Baun et al. 2011 [34] |
Rat | n.d. | n.d. | – | n.d. | n.d. | – | 9.2 ± 0.2 | 32 ± 1 | 14 | Erdling et al. 2013 [90] |
RatPA | 7.6 ± 0.2 | 10 ± 1 | 5 | 7.8 ± 0.1 | 25 ± 1 | 4 | 8.7 ± 0.1 | 28 ± 1 | 4 | Grände et al. 2013 [47] |
Human | n.d. | n.d. | – | 8.2 ± 0.2 | 84 ± 9 | 4 | 8.8 ± 0.4 | 84 ± 9 | 7 | Jansen-Olesen et al. 2004 [48] |
Human | 8.4 ± 0.5 | 27 ± 8 | 5 | n.d. | n.d. | – | 8.1 ± 0.1 | 57 ± 9 | 5 | Grände et al. 2013 [47] |