Fig. 3
From: PACAP and its receptors in cranial arteries and mast cells
Low picomolar concentrations of PACAP, but not VIP, dilate isolated pressurized rat middle meningeal arteries. Cumulative concentrations of PACAP and VIP were administered to arterial segments pressurized to 40 mmHg ex vivo. Arteries were exposed to aCSF containing each concentration of PACAP1–38 or VIP for 20 min. Dilation to PACAP1–38 or VIP are expressed as percentage of maximum dilation obtained in the presence of Ca2+ −free artificial CSF containing 100 μM of the calcium channel blocker diltiazem and 1 μM of the adenylyl cyclase activator forskolin. p < 0.05 by unpaired t test, n = 4. From Syed et al. [55]