Reference | Study design | Number of MO patients who developed migraine-like attacks | Total number of MO patients | Major findings |
---|---|---|---|---|
Schytz et al. [29] | Double-blind crossover | 7 | 12 | PACAP38 induces migraine-like attacks |
Amin et al. [34] | Double-blind randomized | 16 | 22 | PACAP38-induced migraine is associated with sustained dilation of extracranial arteries |
Amin et al. [44] | Double-blind crossover | 18 | 24 | PACAP38-induced migraine-like attacks is associated with altered functional cerebral connectivity |
Guo et al. [49] | Double-blinded | 23 | 32 | PACAP38 induces premonitory symptoms |
Guo et al. [54] | Double-blinded | 23 | 32 | PACAP38 response is not associated with high family load or risk allele status |