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Table 1 Binding affinity constants (pKi) of the drugs used in this study for α1- and α2-adrenoceptors

From: The role of α1- and α2-adrenoceptor subtypes in the vasopressor responses induced by dihydroergotamine in ritanserin-pretreated pithed rats

Drug

α1

α2

Ritanserin

6.71,b

6.21,b

Drugs

α1A

α1B

α1D

α2A

α2B

α2C

5-Methylurapidil

9.02,b

7.42,b

7.62,b

6.23

6.43

6.93

L-765,314

6.34,b

8.34,b

7.34,b

N.D.

N.D.

N.D.

BMY 7378

7.12,b

7.52,b

9.02,b

5.15,b

5.15,b

5.15,b

BRL44408

N.D.

N.D.

N.D.

8.76,b

6.96,b

6.87

Imiloxan

< 48

< 48

< 48

5.58

7.38,b

6.09

JP-1302

N.D.

N.D.

N.D.

5.510

5.810

7.610

Prazosin

9.511,b

9.711,b

9.611,b

5.612

6.912

7.212

Rauwolscine

5.313

5.913

6.413

8.412

8.312

9.112

Dihydroergotamine

8.614,b,a

8.014,b,a

7.814,b,a

8.715

8.015

9.015

  1. Data taken from the following references: 1 [37]; 2 [38]; 3 [39]; 4 [40]; 5 [41]; 6 [42]; 7 [43]; 8 [44]; 9 [45]; 10 [46]; 11 [47]; 12 [48]; 13 [49]; 14 [50]; and 15 [7]
  2. All values have been presented as pKi, except for: a pA2
  3. b Values for rodent receptors
  4. N.D. stands for “not determined”
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The Journal of Headache and Pain

ISSN: 1129-2377

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