Fig. 6

Increases in diastolic blood pressure by i.v. dihydroergotamine (1–3100 μg/kg) after i.v. treatment with: (a) BRL44408; (b) imiloxan; or (c) JP-1302 in animals pretreated (i.v.) with 100 μg/kg ritanserin. Empty symbols depict either: (i) the responses to DHE in the group pretreated with 100 μg/kg ritanserin followed by 1 ml/kg saline (◇, which depicts the same data as those shown in Fig. 3, but it is illustrated here as the control for comparative purposes); or (ii) non-significant responses (△, ▽,⎔ versus control (◇). Solid symbols (▲,▼,) represent significantly different responses (P < 0.05) versus control (◇). ^δ P < 0.05 versus 100 μg/kg BRL44408 (a), 300 μg/kg imiloxan (b) or 300 μg/kg JP-1302 (c). Data are shown as means ± SEM. Δ Diastolic blood pressure stands for “increases in diastolic blood pressure”