Caffeine in the management of patients with headache

Table 3 Pooled results from 3 migraine trials: AAC-130 versus placebo for migraine at 2 and 6 h postdose [73]

	AAC-130 n = 602	Placebo n = 618
Results at 2 hours^a
PID	1.0^b	0.4
Proportion pain-free (%)	21^b	7
Proportion nausea-free (%)	63^c	56
Proportion photophobia-free (%)	35^b	17
Proportion phonophobia-free (%)	37^b	19
Proportion with little or no functional disability (%)	59^b	34
Results at 6 h
PID	1.4^b	0.6
Proportion pain-free (%)	51^b	23
Without nausea (%)	74^b	60
Without photophobia (%)	58^b	31
Without phonophobia (%)	59^b	33
Little or no functional disability (%)	69^b	41

AAC-130, acetaminophen 500 mg, aspirin 500 mg, caffeine 130 mg per 2-tablet dose; PID, pain intensity difference from baseline
^aRescue medication was permitted at 2 h postdose
^b P < 0.001 versus placebo
^c P < 0.01 versus placebo

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