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Table 3 Pooled results from 3 migraine trials: AAC-130 versus placebo for migraine at 2 and 6 h postdose [73]

From: Caffeine in the management of patients with headache

  AAC-130 n = 602 Placebo n = 618
Results at 2 hoursa
 PID 1.0b 0.4
 Proportion pain-free (%) 21b 7
 Proportion nausea-free (%) 63c 56
 Proportion photophobia-free (%) 35b 17
 Proportion phonophobia-free (%) 37b 19
 Proportion with little or no functional disability (%) 59b 34
Results at 6 h   
 PID 1.4b 0.6
 Proportion pain-free (%) 51b 23
 Without nausea (%) 74b 60
 Without photophobia (%) 58b 31
 Without phonophobia (%) 59b 33
 Little or no functional disability (%) 69b 41
  1. AAC-130, acetaminophen 500 mg, aspirin 500 mg, caffeine 130 mg per 2-tablet dose; PID, pain intensity difference from baseline
  2. aRescue medication was permitted at 2 h postdose
  3. b P < 0.001 versus placebo
  4. c P < 0.01 versus placebo