From: Treatment of withdrawal headache in patients with medication overuse headache: a pilot study
Withdrawal therapy groups | |||||
---|---|---|---|---|---|
A:Methylprednisolone | B:Paracetamol | C:Placebo | p value | ||
Headache Intensity (1–3 scale) | |||||
1st day | mean ± SD | 1.8 ± 0.7 | 1.5 ± 0.9 | 2.0 ± 0.7 | |
2nd day | mean ± SD | 1.8 ± 0.5 | 1.9 ± 0.8 | 2.3 ± 0.5 | < 0.001 a |
3rd day | mean ± SD | 1.3 ± 0.7 | 1.5 ± 0.8 | 1.9 ± 0.9 | 0.103b |
4th day | mean ± SD | 1.4 ± 0.6 | 1.4 ± 0.8 | 1.2 ± 0.7 | 0.192c |
5th day | mean ± SD | 1.2 ± 0.8 | 1.1 ± 0.9 | 1.1 ± 0.6 | |
Headache on 5th day (yes/no) | N (%) / N (%) | 15 (79.0) /4 (21.0) | 13 (68.4) / 6 (31.6) | 14 (87.5) / 2 (12.5) | 0.396 |
Associated withdrawal Symptoms | |||||
1st day | N (%) | 15 (79.0) | 13 (68.4) | 15 (79.0) | 0.685 |
2nd day | N (%) | 18 (94.7) | 14 (73.7) | 15 (79.0) | 0.207 |
3rd day | N (%) | 13 (68.4) | 15 (79.0) | 10 (62.5) | 0.554 |
4th day | N (%) | 15 (79.0) | 14 (73.8) | 8 (50.0) | 0.154 |
5th day | N (%) | 12 (63.2) | 10 (52.6) | 6 (37.5) | 0.317 |
Number of Medication Intake | med; IQR | 3; 2–6 | 2; 0–3 | 4; 1–6 | 0.139 |
Withdrawal headache duration (days) | med; IQR | 7; 5–7 | 6; 5–8 | 7; 6.5–8 | 0.5797 |