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Fig. 4 | The Journal of Headache and Pain

Fig. 4

From: Pharmacological analysis of the increases in heart rate and diastolic blood pressure produced by (S)-isometheptene and (R)-isometheptene in pithed rats

Fig. 4

Effects of i.p. pretreatment with vehicle (5% ascorbic acid), reserpine (Reserp), reserpine followed by i.v. administration of saline or reserpine followed by i.v. administration of prazosin (Praz) on the increases in (a, b) heart rate (∆ Heart rate; upper panel) and (c, d) diastolic blood pressure (∆ DBP; lower panel) produced by (S)-isometheptene (0.03-3 mg/kg, i.v.) in pithed rats. *P < 0.05 vs. the corresponding dose in the vehicle curve; # P < 0.05 vs. the corresponding dose in the reserpine curve; n = 5 for each group

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