Fig. 3

Administration of sumatriptan reverses AITC-induced depression of wheel running. a Administration of the high (1 mg/kg), but not the low dose (0.1 mg/kg) of sumatriptan immediately after administration of AITC shortened the duration of AITC-induced depression of wheel running. b Recovery of wheel running in the 3 h following sumatriptan (1 mg/kg; n = 11) administration was significantly greater following administration of 1 mg/kg of sumatriptan compared to rats treated with 0.1 mg/kg (n = 7) or saline (n = 7). *indicates p < 0.05 vs. saline