Fig. 1

Dural injection of AITC depresses home cage wheel running in a concentration-dependent manner. a Administration of 10% AITC depressed wheel running for 3 h. The magnitude and duration of AITC-induced depression of wheel running was greatly reduced when the concentration was reduced to 1%. b Total percent of wheel revolutions during the 3 h following administration of 10% AITC (n = 17) was significantly lower compared to animals receiving 1% AITC (n = 20), mineral oil (n = 7), or saline (n = 14). *indicates p < 0.001 vs. saline, p = 0.016 vs. mineral oil, p = 0.04 vs. 1% AITC