Skip to main content

Table 3 Network meta-analysis results of migraine treatments

From: Network meta-analysis of migraine disorder treatment by NSAIDs and triptans

1 h-Pain-Free A 0.32 (0.20, 0.51) 0.33 (0.19, 0.55) 0.43 (0.11, 1.77) 0.34 (0.16, 0.70) 0.45 (0.13, 1.58) 0.25 (0.04, 1.44) 0.43 (0.12, 1.66) 0.21 (0.07, 0.58) 0.15 (0.00, 2.63) 0.22 (0.04, 1.28) 1 h-Pain-Relief
0.29 (0.21, 0.38) B 1.01 (0.53, 1.92) 1.35 (0.33, 5.59) 1.04 (0.48, 2.26) 1.39 (0.39, 5.13) 0.78 (0.13, 4.65) 1.33 (0.36, 5.22) 0.64 (0.21, 1.96) 0.46 (0.01, 8.52) 0.67 (0.11, 4.04)
0.35 (0.26, 0.46) 1.22 (0.86, 1.75) C 1.34 (0.30, 5.83) 1.03 (0.43, 2.44) 1.39 (0.36, 5.28) 0.77 (0.12, 4.82) 1.32 (0.33, 5.53) 0.63 (0.21, 1.91) 0.46 (0.01, 8.13) 0.66 (0.11, 4.10)
0.46 (0.15, 1.23) 1.61 (0.53, 4.62) 1.32 (0.43, 3.68) D 0.77 (0.16, 3.68) 1.04 (0.16, 6.61) 0.58 (0.06, 5.14) 0.99 (0.15, 6.80) 0.47 (0.08, 2.81) 0.34 (0.01, 7.95) 0.51 (0.05, 4.80)
0.20 (0.12, 0.32) 0.71 (0.46, 1.09) 0.58 (0.35, 0.93) 0.44 (0.15, 1.43) E 1.33 (0.35, 5.08) 0.75 (0.11, 4.98) 1.28 (0.29, 5.75) 0.61 (0.17, 2.15) 0.44 (0.01, 8.67) 0.65 (0.10, 4.36)
0.56 (0.16, 1.93) 1.98 (0.61, 6.77) 1.61 (0.47, 5.55) 1.24 (0.25, 6.38) 2.80 (0.91, 9.23) F 0.56 (0.07, 4.92) 0.97 (0.16, 5.73) 0.46 (0.09, 2.30) 0.33 (0.01, 7.03) 0.48 (0.06, 4.25)
0.18 (0.07, 0.47) 0.64 (0.25, 1.68) 0.53 (0.20, 1.41) 0.41 (0.10, 1.67) 0.91 (0.33, 2.58) 0.33 (0.07, 1.47) G 1.76 (0.20, 15.48) 0.82 (0.11, 6.35) 0.57 (0.01, 18.01) 0.87 (0.11, 6.39)
0.28 (0.13, 0.55) 0.98 (0.46, 2.01) 0.81 (0.37, 1.69) 0.62 (0.17, 2.17) 1.40 (0.59, 3.12) 0.50 (0.12, 1.96) 1.51 (0.46, 4.84) H 0.48 (0.09, 2.46) 0.34 (0.01, 7.70) 0.50 (0.06, 4.55)
0.17 (0.08, 0.30) 0.59 (0.30, 1.07) 0.48 (0.25, 0.85) 0.36 (0.10, 1.25) 0.83 (0.38, 1.71) 0.29 (0.07, 1.10) 0.91 (0.29, 2.62) 0.59 (0.23, 1.50) I 0.73 (0.02, 16.01) 1.04 (0.14, 8.29)
- - - - - - - - - J 1.50 (0.05, 77.84)
0.31 (0.11, 0.79) 1.07 (0.40, 2.87) 0.88 (0.31, 2.39) 0.67 (0.16, 2.95) 1.51 (0.53, 4.36) 0.55 (0.11, 2.45) 1.67 (0.58, 4.74) 1.09 (0.33, 3.76) 1.85 (0.60, 5.91) - K
2 h-Pain-Free A 0.31 (0.25, 0.41) - 0.22 (0.07, 0.72) 0.29 (0.17, 0.39) 0.27 (0.18, 0.37) 0.23 (0.20, 0.86) 0.24 (0.10, 0.30) 0.16 (0.12, 0.21) 0.03 (0.01, 0.05) 0.44 (0.31, 0.50) 2 h-Pain-Relief
0.21 (0.17, 0.26) B - 0.70 (0.26, 1.98) 0.89 (0.47, 1.52) 0.89 (0.44, 1.43) 0.80 (0.67, 2.08) 0.87 (0.25, 0.99) 0.48 (0.39, 0.73) 0.08 (0.03, 0.21) 1.42 (0.75, 2.01)
0.25 (0.18, 0.34) 1.18 (0.83, 1.68) C - - - - - - - -
0.39 (0.25, 0.62) 1.90 (1.17, 3.04) 1.61 (0.95, 2.68) D 1.28 (0.24, 5.80) 1.01 (0.36, 5.46) 1.52 (0.34, 4.55) 0.71 (0.41, 3.52) 0.69 (0.19, 2.78) 0.16 (0.01, 0.39) 1.76 (0.57, 6.84)
0.13 (0.08, 0.19) 0.61 (0.40, 0.92) 0.51 (0.31, 0.84) 0.32 (0.18, 0.58) E 0.93 (0.68, 1.51) 0.99 (0.51, 3.17) 0.70 (0.38, 1.73) 0.60 (0.39, 0.81) 0.08 (0.06, 0.17) 1.40 (1.14, 2.38)
0.28 (0.12, 0.65) 1.33 (0.58, 3.17) 1.13 (0.47, 2.80) 0.70 (0.27, 1.83) 2.20 (0.93, 5.29) F 0.84 (0.54, 4.69) 0.76 (0.56, 1.14) 0.52 (0.42, 1.12) 0.10 (0.04, 0.19) 1.63 (1.25, 1.81)
0.30 (0.16, 0.53) 1.42 (0.77, 2.63) 1.20 (0.61, 2.35) 0.75 (0.36, 1.58) 2.33 (1.18, 4.69) 1.06 (0.39, 2.88) G 1.19 (0.12, 1.22) 0.56 (0.24, 0.95) 0.08 (0.03, 0.25) 1.98 (0.36, 2.40)
0.22 (0.14, 0.35) 1.06 (0.65, 1.72) 0.90 (0.51, 1.56) 0.56 (0.29, 1.07) 1.75 (0.96, 3.21) 0.80 (0.30, 2.04) 0.75 (0.36, 1.58) H 0.61 (0.47, 1.98) 0.15 (0.04, 0.26) 1.99 (1.38, 2.99)
0.10 (0.05, 0.19) 0.46 (0.23, 0.95) 0.39 (0.19, 0.80) 0.24 (0.11, 0.56) 0.77 (0.35, 1.71) 0.35 (0.12, 1.01) 0.33 (0.13, 0.80) 0.44 (0.19, 1.02) I 0.13 (0.08, 0.44) 2.69 (1.51, 4.31)
0.23 (0.10, 0.60) 1.12 (0.44, 2.94) 0.95 (0.37, 2.57) 0.59 (0.21, 1.67) 1.86 (0.69, 5.18) 0.84 (0.24, 2.97) 0.79 (0.27, 2.36) 1.05 (0.38, 2.99) 2.40 (0.77, 7.87) J 14.32 (9.75, 38.13)
0.35 (0.19, 0.63) 1.67 (0.89, 3.10) 1.41 (0.72, 2.77) 0.88 (0.41, 1.88) 2.74 (1.34, 5.69) 1.25 (0.43, 3.43) 1.17 (0.53, 2.58) 1.56 (0.75, 3.39) 3.58 (1.43, 9.05) 1.48 (0.49, 4.40) K
2 h-Nausea-Absence A 0.70 (0.52, 0.92) 0.86 (0.57, 1.29) 0.64 (0.29, 1.38) 0.62 (0.39, 0.97) 1.60 (0.85, 3.00) 1.25 (0.49, 3.15) 1.62 (0.84, 3.19) 0.71 (0.32, 1.61) 0.57 (0.27, 1.22) 0.83 (0.41, 1.69) Recurrence
0.60 (0.27, 1.29) B 1.23 (0.79, 1.93) 0.92 (0.42, 1.99) 0.89 (0.54, 1.45) 2.30 (1.22, 4.33) 1.80 (0.71, 4.57) 2.34 (1.20, 4.60) 1.02 (0.44, 2.34) 0.82 (0.38, 1.79) 1.20 (0.58, 2.47)
0.53 (0.14, 2.00) 0.89 (0.19, 4.11) C 0.75 (0.34, 1.64) 0.72 (0.40, 1.29) 1.86 (0.90, 3.85) 1.46 (0.54, 4.00) 1.90 (0.88, 4.12) 0.83 (0.35, 1.94) 0.67 (0.29, 1.57) 0.96 (0.43, 2.21)
0.61 (0.05, 6.60) 1.01 (0.09, 10.95) 1.14 (0.08, 18.41) D 0.96 (0.40, 2.34) 2.51 (0.94, 6.76) 1.96 (0.58, 6.45) 2.54 (0.96, 6.87) 1.11 (0.38, 3.33) 0.89 (0.31, 2.65) 1.30 (0.47, 3.70)
0.17 (0.05, 0.49) 0.27 (0.08, 0.95) 0.31 (0.06, 1.57) 0.27 (0.02, 3.70) E 2.60 (1.25, 5.32) 2.03 (0.73, 5.64) 2.62 (1.19, 5.87) 1.16 (0.46, 2.92) 0.92 (0.39, 2.23) 1.35 (0.59, 3.10)
0.44 (0.08, 2.48) 0.74 (0.13, 4.34) 0.84 (0.10, 7.13) 0.73 (0.04, 14.17) 2.71 (0.39, 18.41) F 0.79 (0.26, 2.38) 1.01 (0.41, 2.50) 0.45 (0.16, 1.23) 0.36 (0.13, 0.95) 0.52 (0.21, 1.31)
0.58 (0.08, 4.22) 0.98 (0.12, 8.19) 1.11 (0.10, 11.19) 0.97 (0.04, 21.98) 3.57 (0.37, 35.13) 1.31 (0.10, 17.60) G 1.30 (0.42, 3.94) 0.57 (0.17, 1.89) 0.46 (0.14, 1.52) 0.66 (0.23, 1.91)
0.17 (0.03, 0.83) 0.29 (0.06, 1.48) 0.33 (0.04, 2.64) 0.29 (0.02, 4.94) 1.06 (0.15, 7.12) 0.40 (0.04, 3.84) 0.30 (0.02, 3.62) H 0.44 (0.15, 1.25) 0.35 (0.13, 0.97) 0.51 (0.20, 1.32)
0.47 (0.06, 3.89) 0.77 (0.09, 7.04) 0.87 (0.09, 8.93) 0.78 (0.03, 17.70) 2.82 (0.28, 29.29) 1.04 (0.07, 15.63) 0.81 (0.04, 14.26) 2.66 (0.21, 37.40) I 0.80 (0.27, 2.40) 1.16 (0.40, 3.43)
0.37 (0.02, 7.04) 0.61 (0.03, 11.94) 0.70 (0.03, 17.74) 0.61 (0.01, 27.58) 2.22 (0.10, 54.60) 0.83 (0.03, 25.26) 0.63 (0.02, 23.22) 2.05 (0.08, 61.86) 0.79 (0.02, 28.38) J 1.44 (0.52, 4.05)
0.73 (0.08, 6.87) 1.21 (0.12, 12.49) 1.38 (0.10, 17.99) 1.20 (0.05, 32.12) 4.40 (0.38, 54.35) 1.65 (0.10, 29.14) 1.27 (0.06, 25.07) 4.10 (0.29, 65.07) 1.58 (0.07, 35.45) 1.97 (0.05, 76.90) K
All Adverse Event A 0.53 (0.42, 0.67) 0.46 (0.32, 0.64) 0.77 (0.41, 1.49) 0.75 (0.52, 1.05) 1.09 (0.45, 2.60) 1.43 (0.76, 2.86) 0.90 (0.59, 1.33) 5.81 (0.99, 35.03) 1.58 (0.54, 4.83) 0.30 (0.03, 1.52) Nausea
0.31 (0.23, 0.41) B 0.86 (0.60, 1.23) 1.45 (0.77, 2.82) 1.40 (0.99, 1.97) 2.03 (0.85, 4.89) 2.68 (1.40, 5.69) 1.69 (1.08, 2.60) 10.84 (1.88, 66.09) 2.96 (1.01, 9.28) 0.56 (0.06, 2.91)
0.37 (0.24, 0.54) 1.17 (0.74, 1.87) C 1.68 (0.86, 3.32) 1.62 (1.04, 2.59) 2.37 (0.93, 5.98) 3.11 (1.52, 6.94) 1.96 (1.15, 3.31) 12.66 (2.11, 78.62) 3.44 (1.11, 11.21) 0.64 (0.07, 3.42)
0.64 (0.33, 1.24) 2.04 (1.04, 4.10) 1.74 (0.81, 3.76) D 0.96 (0.46, 1.96) 1.40 (0.47, 4.03) 1.87 (0.74, 4.87) 1.16 (0.54, 2.45) 7.36 (1.14, 49.86) 2.03 (0.56, 7.42) 0.39 (0.04, 2.18)
0.41 (0.26, 0.63) 1.31 (0.82, 2.10) 1.11 (0.63, 1.97) 0.64 (0.29, 1.39) E 1.46 (0.60, 3.45) 1.92 (0.92, 4.30) 1.21 (0.70, 2.00) 7.71 (1.30, 47.29) 2.10 (0.69, 6.80) 0.39 (0.05, 2.24)
0.26 (0.12, 0.54) 0.84 (0.40, 1.72) 0.71 (0.30, 1.59) 0.41 (0.15, 1.06) 0.64 (0.29, 1.39) F 1.33 (0.45, 4.04) 0.83 (0.31, 2.14) 5.36 (0.72, 40.60) 1.47 (0.35, 6.08) 0.27 (0.03, 1.85)
0.89 (0.33, 2.35) 2.84 (1.06, 7.81) 2.42 (0.86, 6.96) 1.39 (0.43, 4.47) 2.17 (0.78, 6.19) 3.39 (1.02, 11.43) G 0.63 (0.28, 1.32) 3.99 (0.60, 26.74) 1.10 (0.30, 4.10) 0.21 (0.02, 1.16)
0.51 (0.10, 2.70) 1.63 (0.31, 9.07) 1.38 (0.25, 7.82) 0.79 (0.13, 4.89) 1.24 (0.22, 6.92) 1.94 (0.32, 12.28) 0.57 (0.09, 3.92) H 6.48 (1.06, 39.57) 1.75 (0.55, 5.65) 0.34 (0.04, 1.79)
0.64 (0.26, 1.60) 2.05 (0.83, 5.27) 1.76 (0.68, 4.41) 1.00 (0.33, 3.08) 1.57 (0.59, 4.27) 2.45 (0.80, 7.91) 0.72 (0.19, 2.76) 1.27 (0.19, 8.49) I 0.28 (0.03, 2.14) 0.05 (0.00, 0.56)
0.95 (0.35, 2.54) 3.04 (1.12, 8.23) 2.58 (0.90, 7.53) 1.48 (0.45, 4.84) 2.33 (0.79, 6.74) 3.62 (1.09, 12.42) 1.07 (0.26, 4.27) 1.85 (0.26, 12.93) 1.48 (0.39, 5.51) J 0.18 (0.02, 1.37)
0.26 (0.11, 0.58) 0.82 (0.35, 1.91) 0.70 (0.28, 1.73) 0.40 (0.14, 1.13) 0.63 (0.25, 1.57) 0.98 (0.34, 2.92) 0.29 (0.08, 0.97) 0.51 (0.08, 3.19) 0.40 (0.12, 1.32) 0.27 (0.07, 0.97) K
Rescue Medication A 0.43 (0.33, 0.56) - - 0.33 (0.17, 0.61) 0.52 (0.25, 1.09) 0.28 (0.14, 0.55) 0.28 (0.17, 0.46) 0.25 (0.08, 0.79) 1.63 (0.43, 6.38) 0.44 (0.24, 0.81)  
2.32 (1.79, 3.05) B - - 0.77 (0.38, 1.50) 1.21 (0.60, 2.56) 0.66 (0.31, 1.32) 0.64 (0.38, 1.10) 0.59 (0.19, 1.83) 3.81 (0.97, 15.25) 1.02 (0.54, 1.95)  
3.03 (1.63, 5.90) 1.30 (0.67, 2.62) C - - - - - - - -  
- - - D - - - - - - -  
- - - - E 1.59 (0.61, 4.19) 0.87 (0.36, 2.05) 0.84 (0.38, 1.92) 0.77 (0.21, 2.95) 5.00 (1.18, 22.48) 1.34 (0.57, 3.29)  
1.91 (0.92, 3.97) 0.83 (0.39, 1.68) - - 0.63 (0.24, 1.65) F 0.55 (0.20, 1.46) 0.53 (0.22, 1.27) 0.49 (0.12, 1.85) 3.15 (0.68, 14.14) 0.85 (0.32, 2.13)  
3.52 (1.82, 7.15) 1.52 (0.76, 3.20) - - 1.15 (0.49, 2.79) 1.82 (0.69, 5.10) G 0.97 (0.43, 2.31) 0.90 (0.24, 3.31) 5.77 (1.33, 27.19) 1.55 (0.67, 3.70)  
3.62 (2.16, 6.01) 1.56 (0.91, 2.63) - - 1.20 (0.52, 2.61) 1.88 (0.79, 4.48) 1.03 (0.43, 2.34) H 0.92 (0.27, 3.28) 5.92 (1.48, 25.27) 1.59 (0.72, 3.54)  
3.94 (1.26, 12.29) 1.69 (0.55, 5.32) - - 1.30 (0.34, 4.69) 2.05 (0.54, 8.09) 1.11 (0.30, 4.22) 1.09 (0.30, 3.77) I 6.50 (1.11, 37.90) 1.74 (0.48, 6.35)  
0.61 (0.16, 2.30) 0.26 (0.07, 1.03) - - 0.20 (0.04, 0.84) 0.32 (0.07, 1.48) 0.17 (0.04, 0.75) 0.17 (0.04, 0.68) 0.15 (0.03, 0.90) J 0.27 (0.06, 1.13)  
2.27 (1.23, 4.18) 0.98 (0.51, 1.84) - - 0.75 (0.30, 1.76) 1.17 (0.47, 3.10) 0.64 (0.27, 1.49) 0.63 (0.28, 1.39) 0.58 (0.16, 2.07) 3.73 (0.89, 16.46) K  
  1. Treatment: A Placebo; B Sumatriptan; C Zolmitriptan; D Almotriptan; E Rizatriptan; F Naratriptan; G Ibuprofen; H Sumatriptan-Naproxen; I Eletriptan; J Diclofenacpotassium; K Aspirin
  2. Values in bold indicate significant difference