From: Network meta-analysis of migraine disorder treatment by NSAIDs and triptans
Comparison | 1Â h-pain-free | 1Â h-pain-relief | 2Â h-pain-free | 2Â h-pain-relief | 2Â h-nausea-absence | Rescue medication | Recurrence | All-adverse event | Nausea |
---|---|---|---|---|---|---|---|---|---|
Sumatriptan vs Placebo | 2.89 (1.74, 4.81) | 1.71 (1.34, 2.19) | 2.93 (2.49, 3.44) | 1.94 (1.76, 2.14) | 1.08 (0.90, 1.30) | 0.62 (0.54, 0.71) | 1.34 (1.1, 1.63) | 1.88 (1.59, 2.23) | 1.83 (1.45, 2.32) |
Zolmitriptan vs Placebo | 2.45 (2.08, 2.90) | 1.94 (1.73, 2.18) | 2.75 (2.06, 3.68) | 2.17 (1.88, 2.50) | 1.44 (1.29, 1.62) | 0.56 (0.51, 0.62) | 1.09 (0.67, 1.76) | 1.94 (1.49, 2.53) | 2.17 (1.51, 3.12) |
Almotriptan vs Placebo | 1.99 (0.99, 3.99) | 1.32 (0.89, 1.94) | 1.66 (1.09, 2.53) | 1.57 (1.29, 1.90) | 1.37 (0.97, 1.93) | 0.53 (0.23, 1.21) | 1.58 (0.87, 2.84) | 1.48 (0.94, 2.33) | 0.57 (0.21, 1.53) |
Rizatriptan vs Placebo | 3.25 (1.79, 5.90) | 1.71 (1.21, 2.43) | 5.36 (4.09, 7.04) | 2.12 (1.74, 2.58) | 1.39 (1.24, 1.55) | 0.60 (0.42, 0.87) | 1.43 (1.14, 1.8) | 1.68 (1.44, 1.96) | 1.24 (0.88, 1.76) |
Naratriptan vs Placebo | 3.50 (0.43, 28.8) | 1.72 (1.16, 2.56) | 2.75 (1.66, 4.56) | 1.99 (1.50, 2.62) | 1.25 (1.00, 1.57) | 0.52 (0.38, 0.71) | 1.02 (0.61, 1.7) | 1.81 (1.10, 2.98) | 1.00 (0.25, 4.08) |
Ibuprofen vs Placebo | 3.14 (1.31, 7.54) | 2.77 (1.68, 4.55) | 2.31 (1.70, 3.14) | 1.83 (1.32, 2.53) | 1.22 (0.97, 1.53) | 0.51 (0.35, 0.74) | 0.82 (0.4, 1.69) | 1.01 (0.54, 1.87) | 0.77 (0.55, 1.09) |
Sumatriptan-Naproxen vs Placebo | 3.37 (0.5, 22.48) | 1.66 (0.8, 3.41) | 2.81 (2.11, 3.74) | 2.21 (1.87, 2.61) | 1.09 (0.96, 1.23) | 0.48 (0.42, 0.57) | 0.55 (0.39, 0.78) | 1.88 (0.82, 4.31) | 1.12 (0.62, 2.03) |
Eletriptan vs Placebo | 18.4 (4.54, 74.9) | 3.63 (2.23, 5.92) | 7.41 (5.16, 10.63) | 2.70 (2.23, 3.27) | 1.30 (1.11, 1.53) | 0.38 (0.30, 0.48) | 1.52 (1.16, 2) | 0.91 (0.75, 1.11) | 0.19 (0.04, 0.85) |
Diclofenacpotassium vs Placebo | 2.00 (0.79, 5.05) | 4.00 (0.46, 35.0) | 3.10 (2.02, 4.74) | 3.68 (2.71, 5.01) | 1.32 (0.91, 1.91) | 1.40 (1.01, 1.94) | 1.64 (1.25, 2.15) | 1.02 (0.60, 1.74) | 0.48 (0.17, 1.41) |
Aspirin vs Placebo | - | 3.04 (1.87, 4.96) | 2.07 (1.57, 2.72) | 1.56 (1.29, 1.89) | 1.07 (0.84, 1.37) | 0.66 (0.56, 0.79) | 1.09 (0.81, 1.46) | 2.31 (1.15, 4.64) | 2.99 (0.60, 15.0) |
Zolmitriptan vs Sumatriptan | 0.86 (0.66, 1.12) | 1.01 (0.88, 1.14) | 0.97 (0.82, 1.14) | 1.00 (0.90, 1.11) | - | 0.97 (0.68, 1.40) | 1.06 (0.89, 1.26) | 1.08 (0.97, 1.21) | 1.11 (0.70, 1.76) |
Almotriptan vs Sumatriptan | - | 0.98 (0.78, 1.22) | 0.79 (0.64, 0.97) | 1.02 (0.85, 1.24) | 1.03 (0.85, 1.25) | 1.13 (0.93, 1.37) | 1.16 (0.9, 1.5) | 0.52 (0.37, 0.73) | 0.64 (0.32, 1.30) |
Rizatriptan vs Sumatriptan | 1.49 (1.16, 1.91) | 1.11 (0.95, 1.30) | 1.20 (1.08, 1.34) | 1.03 (0.91, 1.16) | 1.08 (0.96, 1.23) | 0.90 (0.63, 1.28) | 1.07 (0.93, 1.24) | 0.88 (0.75, 1.04) | 0.74 (0.55, 1.00) |
Naratriptan vs Sumatriptan | - | 0.98 (0.63, 1.50) | 0.96 (0.56, 1.62) | 0.95 (0.72, 1.27) | 1.02 (0.78, 1.33) | 1.35 (0.79, 2.31) | 0.61 (0.47, 0.79) | 0.94 (0.70, 1.26) | 0.78 (0.26, 2.28) |
Ibuprofen vs Sumatriptan | 1.87 (0.90, 3.89) | 1.30 (0.87, 1.96) | 0.90 (0.62, 1.30) | 1.09 (0.80, 1.49) | - | 1.01 (0.71, 1.43) | 0.84 (0.53, 1.32) | 1.07 (0.07, 17.2) | - |
Sumatriptan-Naproxen vs Sumatriptan | 2.03 (0.91, 4.54) | 1.28 (0.86, 1.91) | 1.41 (1.16, 1.72) | 1.20 (1.04, 1.40) | 1.07 (0.93, 1.24) | 0.66 (0.55, 0.79) | 0.65 (0.52, 0.81) | - | 1.04 (0.59, 1.84) |
Eletriptan vs Sumatriptan | 1.42 (0.93, 2.15) | 1.29 (1.05, 1.58) | 1.35 (1.10, 1.65) | 1.12 (0.96, 1.31) | 1.09 (0.94, 1.27) | 0.74 (0.59, 0.93) | 0.94 (0.75, 1.18) | 0.83 (0.69, 1.01) | - |
Diclofenacpotassium vs Sumatriptan | 1.19 (0.54, 2.63) | - | - | - | 1.25 (0.87, 1.81) | - | 0.88 (0.54, 1.43) | 0.43 (0.26, 0.71) | 0.67 (0.15, 3.03) |
Aspirin vs Sumatriptan | - | 1.43 (0.97, 2.13) | 0.83 (0.59, 1.16) | 0.97 (0.76, 1.25) | 1.03 (0.71, 1.50) | 1.09 (0.83, 1.42) | 1.01 (0.73, 1.4) | 2.55 (0.11, 61.41) | - |
Almotriptan vs Zolmitriptan | - | - | 0.90 (0.73, 1.11) | 0.93 (0.77, 1.12) | - | 0.99 (0.74, 1.32) | 1.07 (0.8, 1.42) | - | 1.18 (0.52, 2.65) |
Rizatriptan vs Zolmitriptan | 1.22 (0.73, 2.02) | 1.20 (0.88, 1.63) | 1.22 (0.90, 1.66) | 1.05 (0.81, 1.35) | 1.12 (0.87, 1.44) | - | 0.96 (0.68, 1.36) | 0.89 (0.63, 1.27) | - |
Eletriptan vs Zolmitriptan | 1.59 (0.96, 2.64) | 1.39 (1.06, 1.81) | 1.93 (1.50, 2.49) | 1.13 (0.93, 1.38) | 1.10 (0.91, 1.34) | - | 0.92 (0.68, 1.23) | 1.08 (0.85, 1.37) | - |
Naratriptan vs Rizatriptan | 0.35 (0.14, 0.84) | 0.73 (0.49, 1.08) | 0.46 (0.31, 0.69) | 0.70 (0.51, 0.97) | 0.86 (0.63, 1.18) | - | 0.63 (0.41, 0.96) | 0.70 (0.44, 1.09) | 0.47 (0.17, 1.28) |
Ibuprofen vs Rizatriptan | - | - | 0.86 (0.40, 1.85) | 0.72 (0.39, 1.35) | - | 1.75 (0.82, 3.74) | - | 0.91 (0.33, 2.53) | - |
Aspirin vs Ibuprofen | - | 1.10 (0.75, 1.61) | 0.81 (0.54, 1.19) | 0.87 (0.64, 1.19) | - | 1.09 (0.77, 1.53) | 1.05 (0.66, 1.68) | 1.05 (0.66, 1.68) | - |