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Table 2 Direct MA comparison of migraine treatments

From: Network meta-analysis of migraine disorder treatment by NSAIDs and triptans

Comparison 1 h-pain-free 1 h-pain-relief 2 h-pain-free 2 h-pain-relief 2 h-nausea-absence Rescue medication Recurrence All-adverse event Nausea
Sumatriptan vs Placebo 2.89 (1.74, 4.81) 1.71 (1.34, 2.19) 2.93 (2.49, 3.44) 1.94 (1.76, 2.14) 1.08 (0.90, 1.30) 0.62 (0.54, 0.71) 1.34 (1.1, 1.63) 1.88 (1.59, 2.23) 1.83 (1.45, 2.32)
Zolmitriptan vs Placebo 2.45 (2.08, 2.90) 1.94 (1.73, 2.18) 2.75 (2.06, 3.68) 2.17 (1.88, 2.50) 1.44 (1.29, 1.62) 0.56 (0.51, 0.62) 1.09 (0.67, 1.76) 1.94 (1.49, 2.53) 2.17 (1.51, 3.12)
Almotriptan vs Placebo 1.99 (0.99, 3.99) 1.32 (0.89, 1.94) 1.66 (1.09, 2.53) 1.57 (1.29, 1.90) 1.37 (0.97, 1.93) 0.53 (0.23, 1.21) 1.58 (0.87, 2.84) 1.48 (0.94, 2.33) 0.57 (0.21, 1.53)
Rizatriptan vs Placebo 3.25 (1.79, 5.90) 1.71 (1.21, 2.43) 5.36 (4.09, 7.04) 2.12 (1.74, 2.58) 1.39 (1.24, 1.55) 0.60 (0.42, 0.87) 1.43 (1.14, 1.8) 1.68 (1.44, 1.96) 1.24 (0.88, 1.76)
Naratriptan vs Placebo 3.50 (0.43, 28.8) 1.72 (1.16, 2.56) 2.75 (1.66, 4.56) 1.99 (1.50, 2.62) 1.25 (1.00, 1.57) 0.52 (0.38, 0.71) 1.02 (0.61, 1.7) 1.81 (1.10, 2.98) 1.00 (0.25, 4.08)
Ibuprofen vs Placebo 3.14 (1.31, 7.54) 2.77 (1.68, 4.55) 2.31 (1.70, 3.14) 1.83 (1.32, 2.53) 1.22 (0.97, 1.53) 0.51 (0.35, 0.74) 0.82 (0.4, 1.69) 1.01 (0.54, 1.87) 0.77 (0.55, 1.09)
Sumatriptan-Naproxen vs Placebo 3.37 (0.5, 22.48) 1.66 (0.8, 3.41) 2.81 (2.11, 3.74) 2.21 (1.87, 2.61) 1.09 (0.96, 1.23) 0.48 (0.42, 0.57) 0.55 (0.39, 0.78) 1.88 (0.82, 4.31) 1.12 (0.62, 2.03)
Eletriptan vs Placebo 18.4 (4.54, 74.9) 3.63 (2.23, 5.92) 7.41 (5.16, 10.63) 2.70 (2.23, 3.27) 1.30 (1.11, 1.53) 0.38 (0.30, 0.48) 1.52 (1.16, 2) 0.91 (0.75, 1.11) 0.19 (0.04, 0.85)
Diclofenacpotassium vs Placebo 2.00 (0.79, 5.05) 4.00 (0.46, 35.0) 3.10 (2.02, 4.74) 3.68 (2.71, 5.01) 1.32 (0.91, 1.91) 1.40 (1.01, 1.94) 1.64 (1.25, 2.15) 1.02 (0.60, 1.74) 0.48 (0.17, 1.41)
Aspirin vs Placebo - 3.04 (1.87, 4.96) 2.07 (1.57, 2.72) 1.56 (1.29, 1.89) 1.07 (0.84, 1.37) 0.66 (0.56, 0.79) 1.09 (0.81, 1.46) 2.31 (1.15, 4.64) 2.99 (0.60, 15.0)
Zolmitriptan vs Sumatriptan 0.86 (0.66, 1.12) 1.01 (0.88, 1.14) 0.97 (0.82, 1.14) 1.00 (0.90, 1.11) - 0.97 (0.68, 1.40) 1.06 (0.89, 1.26) 1.08 (0.97, 1.21) 1.11 (0.70, 1.76)
Almotriptan vs Sumatriptan - 0.98 (0.78, 1.22) 0.79 (0.64, 0.97) 1.02 (0.85, 1.24) 1.03 (0.85, 1.25) 1.13 (0.93, 1.37) 1.16 (0.9, 1.5) 0.52 (0.37, 0.73) 0.64 (0.32, 1.30)
Rizatriptan vs Sumatriptan 1.49 (1.16, 1.91) 1.11 (0.95, 1.30) 1.20 (1.08, 1.34) 1.03 (0.91, 1.16) 1.08 (0.96, 1.23) 0.90 (0.63, 1.28) 1.07 (0.93, 1.24) 0.88 (0.75, 1.04) 0.74 (0.55, 1.00)
Naratriptan vs Sumatriptan - 0.98 (0.63, 1.50) 0.96 (0.56, 1.62) 0.95 (0.72, 1.27) 1.02 (0.78, 1.33) 1.35 (0.79, 2.31) 0.61 (0.47, 0.79) 0.94 (0.70, 1.26) 0.78 (0.26, 2.28)
Ibuprofen vs Sumatriptan 1.87 (0.90, 3.89) 1.30 (0.87, 1.96) 0.90 (0.62, 1.30) 1.09 (0.80, 1.49) - 1.01 (0.71, 1.43) 0.84 (0.53, 1.32) 1.07 (0.07, 17.2) -
Sumatriptan-Naproxen vs Sumatriptan 2.03 (0.91, 4.54) 1.28 (0.86, 1.91) 1.41 (1.16, 1.72) 1.20 (1.04, 1.40) 1.07 (0.93, 1.24) 0.66 (0.55, 0.79) 0.65 (0.52, 0.81) - 1.04 (0.59, 1.84)
Eletriptan vs Sumatriptan 1.42 (0.93, 2.15) 1.29 (1.05, 1.58) 1.35 (1.10, 1.65) 1.12 (0.96, 1.31) 1.09 (0.94, 1.27) 0.74 (0.59, 0.93) 0.94 (0.75, 1.18) 0.83 (0.69, 1.01) -
Diclofenacpotassium vs Sumatriptan 1.19 (0.54, 2.63) - - - 1.25 (0.87, 1.81) - 0.88 (0.54, 1.43) 0.43 (0.26, 0.71) 0.67 (0.15, 3.03)
Aspirin vs Sumatriptan - 1.43 (0.97, 2.13) 0.83 (0.59, 1.16) 0.97 (0.76, 1.25) 1.03 (0.71, 1.50) 1.09 (0.83, 1.42) 1.01 (0.73, 1.4) 2.55 (0.11, 61.41) -
Almotriptan vs Zolmitriptan - - 0.90 (0.73, 1.11) 0.93 (0.77, 1.12) - 0.99 (0.74, 1.32) 1.07 (0.8, 1.42) - 1.18 (0.52, 2.65)
Rizatriptan vs Zolmitriptan 1.22 (0.73, 2.02) 1.20 (0.88, 1.63) 1.22 (0.90, 1.66) 1.05 (0.81, 1.35) 1.12 (0.87, 1.44) - 0.96 (0.68, 1.36) 0.89 (0.63, 1.27) -
Eletriptan vs Zolmitriptan 1.59 (0.96, 2.64) 1.39 (1.06, 1.81) 1.93 (1.50, 2.49) 1.13 (0.93, 1.38) 1.10 (0.91, 1.34) - 0.92 (0.68, 1.23) 1.08 (0.85, 1.37) -
Naratriptan vs Rizatriptan 0.35 (0.14, 0.84) 0.73 (0.49, 1.08) 0.46 (0.31, 0.69) 0.70 (0.51, 0.97) 0.86 (0.63, 1.18) - 0.63 (0.41, 0.96) 0.70 (0.44, 1.09) 0.47 (0.17, 1.28)
Ibuprofen vs Rizatriptan - - 0.86 (0.40, 1.85) 0.72 (0.39, 1.35) - 1.75 (0.82, 3.74) - 0.91 (0.33, 2.53) -
Aspirin vs Ibuprofen - 1.10 (0.75, 1.61) 0.81 (0.54, 1.19) 0.87 (0.64, 1.19) - 1.09 (0.77, 1.53) 1.05 (0.66, 1.68) 1.05 (0.66, 1.68) -
  1. Values in bold indicate significant difference