The potential impact of primary headache disorders on stroke risk

Table 4 Incidence of stroke and stroke subtype and multivariate Cox proportional hazards regression analysis measured hazard ratio for study cohort by PHDs subtype

Variable	PHDs cohort			Comparison cohort			Adjusted HR (95% CI)
	Event	PYs	Rate	Event	PYs	Rate	Adjusted HR (95% CI)
Total
All strokes	100	6,149	162.62	287	24,742	116.00	1.40 (1.13–1.68)^**
Haemorrhagic	4	6,149	6.50	30	24,742	12.12	0.55 (0.25–1.58)
Ischaemic	96	6,149	156.11	257	24,742	103.87	1.49 (1.15–1.98)^**
Migraine
All strokes	65	5,235	124.16	287	24,742	116.00	1.15 (1.04–1.69)*
Haemorrhagic	3	5,235	5.73	30	24,742	12.12	0.44 (0.21–1.57)
Ischaemic	62	5,235	118.43	257	24,742	103.87	1.22 (1.13–1.97)*
Tension-type headache
All strokes	35	996	351.41	287	24,742	116.00	2.16 (1.25–2.77)**
Haemorrhagic	1	996	10.04	30	24,742	12.12	0.86 (0.23–1.64)
Ischaemic	34	996	341.37	257	24,742	103.87	2.29 (1.22–2.80)**

Model adjusted for age, sex, hypertension, DM, IHD, hyperlipidaemia, AF
Abbreviation: PYs person-years, Rate incidence rate, per 10,000 person-years, PHDs primary headache disorders, DM diabetes mellitus, IHD ischaemic heart disease, AF atrial fibrillation
*p < 0.05; **p < 0.01

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