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Table 2 Incidence of stroke and stroke subtype and multivariate Cox proportional hazards regression analysis measured hazard ratio for study cohort

From: The potential impact of primary headache disorders on stroke risk

Variable

PHDs cohort

Comparison cohort

Adjusted HR (95% CI)

Event

PYs

Rate

Event

PYs

Rate

All strokes

100

6,149

162.62

287

24,742

116.00

1.40 (1.13–1.68)**

 Haemorrhagic

4

6,149

6.50

30

24,742

12.12

0.55 (0.25–1.58)

 Ischaemic

96

6,149

156.11

257

24,742

103.87

1.49 (1.15–1.98)**

<45 years

All strokes

13

2,951

44.05

33

12,539

26.32

1.66 (0.79–2.97)

 Haemorrhagic

1

2,951

3.39

7

12,539

5.58

0.63 (0.10–4.00)

 Ischaemic

12

2,951

40.66

26

12,539

20.73

1.95 (0.97–3.74)

45–64 years

All strokes

50

2,568

194.73

124

9,222

134.46

1.43 (1.03–2.00)*

 Haemorrhagic

3

2,568

11.68

13

9,222

14.10

0.81 (0.15–2.77)

 Ischaemic

47

2,568

183.04

111

9,222

120.36

1.50 (1.11–2.10)*

≧65 years

All strokes

37

631

586.68

130

2,981

436.14

1.33 (0.91–1.91)

 Haemorrhagic

0

631

0

10

2,981

33.55

0

 Ischaemic

37

631

586.68

120

2,981

402.59

1.42 (0.99–2.08)

Male

All strokes

35

1,730

202.36

101

6,918

146.00

1.37 (0.91–2.02)

 Haemorrhagic

3

1,730

17.35

15

6,918

21.68

0.80 (0.25–2.70)

 Ischaemic

32

1,730

185.02

86

6,918

124.32

1.46 (0.91–2.10)

Female

All strokes

65

4,420

147.06

186

17,825

104.35

1.40 (1.04–1.80)*

 Haemorrhagic

1

4,420

2.26

15

17,825

8.42

0.26 (0.02–2.00)

 Ischaemic

64

4,420

144.80

171

17,825

95.93

1.49 (1.13–1.90)**

  1. Model adjusted for age, sex, hypertension, DM, IHD, hyperlipidaemia, AF
  2. Abbreviation: PYs person-years, Rate incidence rate, per 10,000 person-years, PHDs primary headache disorders, DM diabetes mellitus, IHD ischaemic heart disease, AF atrial fibrillation; HR: hazard ratio
  3. *p < 0.05; **p < 0.01