Fig. 7
Effect of sulforaphane pretreatment on front paw withdrawal and periorbital thresholds in NTG-induced rats. a The front paw withdrawal thresholds significantly decreased as early as 0.5 h and persisted for 4 h in the NTG group compared to those in the control group, whereas the thresholds significantly increased as early as 0.5 h and persisted for 4 h in the SFN plus NTG group compared to those in the H2O plus NTG group. b The periorbital withdrawal thresholds also significantly decreased as early as 0.5 h and persisted for 4 h in the NTG group, while the thresholds significantly increased as early as 1 h and persisted for 4 h in the SFN plus NTG group compared to those in the H2O plus NTG group. (*P < 0.05, **P < 0.01 for NTG vs control group, # P < 0.05 for SFN + NTG vs H2O + NTG group. n = 6 per group)