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Table 4 Summary of efficacy outcome measures of occipital nerve stimulation for chronic migraine

From: Long-term outcomes of occipital nerve stimulation for chronic migraine: a cohort of 53 patients

Outcome measure

Prior to ONS

Post-ONS

Percentage change

Mean change (95 % CI)

p Value

Whole cohort (n = 53)

 Headache daysa (±SD)

29.57 (±2.12)

23.91 (±10.04)

20.0 % (±32.91)

5.66

< 0.001*

  Range

18–30

0–30

0–100

(3.07, 8.25)

 Moderate-to-severe headache daysa (±SD)

26.51 (±6.48)

18.00 (±12.79)

37.1 % (±41.27)

8.51

< 0.001*

  Range

5–30

0–30

0–100

(5.63, 11.38)

 Average daily pain intensity VRS (±SD)

6.00 (±1.71)

4.66 (±2.59)

27.8 % (±32.87)

1.34

< 0.001*

  Range (VRS)

3–9

0–10

0–100.0

(0.64, 2.03)

 Average daily headache hours (±SD)

16.06 (±5.38)

11.52 (±7.12)

31.6 % (±37.12)

4.54

< 0.001*

  Range (hours)

2–24

0–24

0–100

(2.62, 6.45)

 Mean Patient estimated benefit (±SD)

 

31.7 % (±33.12)

   

  Range

 

0–100

   

Chronic migraine alone (n = 35)

 Headache daysa (±SD)

29.34 (±18–30)

26.23 (±8.26)

12.0 % (±26.29)

3.11

< 0.001*

  Range

18–30

2–30

0–93

(0.79, 5.43)

 Moderate-to-severe headache daysa (±SD)

26.83 (±6.74)

21.03 (±11.33)

26.0 %(±34.58)

5.80

0.010*

  Range

5–30

0–30

0–100

(2.76, 8.83)

 Average daily pain intensity VRS (±SD)

6.09 (±1.63)

4.89 (±2.34)

23.7 % (±28.40)

1.20

0.003*

  Range (VRS)

3–9

0–9

0–100

(0.43, 1.96)

 Average daily headache hours (±SD)

15.10 (±4.15)

12.44 (±6.18)

24.5 % (±34.24)

2.75

0.003*

  Range (hours)

2.0–24.0

0–24.0

0–100

(0.99, 4.50)

 Mean Patient estimated benefit (±SD)

 

30.0 % (±29.77)

   

  Range

 

0–95

   

Multiple headache phenotypes (n = 18)

 Headache daysa (±SD)

30.00 (±0.0)

19.39 (±11.80)

35.3 % (±39.37)

10.61

0.001

  Range

30

0–30

0–100

(4.73, 16.48)

 Moderate-to-severe headache daysa (±SD)

25.94 (±5.90)

13.78 (±13.97)

58.7 % (±45.48)

12.16

< 0.001

  Range

10–30

0–30

0–100

(6.63, 17.69)

 Average daily pain intensity VRS (±SD)

5.83 (±1.88)

4.22 (±3.04)

23.7 % (±28.40)

1.61

0.039

  Range (VRS)

3–9

0–10

0–100

(0.09, 3.12)

 Average daily headache hours (±SD)

17.72 (±6.96)

9.80 (±8.53)

45.4 % (±39.56)

7.91

0.001

  Range (hours)

5.0–24.0

0.0–24.0

0–100

(3.62, 12.21)

 Mean Patient estimated benefit (±SD)

 

35.2 % (±39.53)

   

  Range

 

0–100

   
  1. CI confidence interval, ONS occipital nerve stimulation, SD standard deviation, VRS verbal rating scale
  2. *P value less than 0.05; atime period one month