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Table 4 Summary of efficacy outcome measures of occipital nerve stimulation for chronic migraine

From: Long-term outcomes of occipital nerve stimulation for chronic migraine: a cohort of 53 patients

Outcome measure Prior to ONS Post-ONS Percentage change Mean change (95 % CI) p Value
Whole cohort (n = 53)
 Headache daysa (±SD) 29.57 (±2.12) 23.91 (±10.04) 20.0 % (±32.91) 5.66 < 0.001*
  Range 18–30 0–30 0–100 (3.07, 8.25)
 Moderate-to-severe headache daysa (±SD) 26.51 (±6.48) 18.00 (±12.79) 37.1 % (±41.27) 8.51 < 0.001*
  Range 5–30 0–30 0–100 (5.63, 11.38)
 Average daily pain intensity VRS (±SD) 6.00 (±1.71) 4.66 (±2.59) 27.8 % (±32.87) 1.34 < 0.001*
  Range (VRS) 3–9 0–10 0–100.0 (0.64, 2.03)
 Average daily headache hours (±SD) 16.06 (±5.38) 11.52 (±7.12) 31.6 % (±37.12) 4.54 < 0.001*
  Range (hours) 2–24 0–24 0–100 (2.62, 6.45)
 Mean Patient estimated benefit (±SD)   31.7 % (±33.12)    
  Range   0–100    
Chronic migraine alone (n = 35)
 Headache daysa (±SD) 29.34 (±18–30) 26.23 (±8.26) 12.0 % (±26.29) 3.11 < 0.001*
  Range 18–30 2–30 0–93 (0.79, 5.43)
 Moderate-to-severe headache daysa (±SD) 26.83 (±6.74) 21.03 (±11.33) 26.0 %(±34.58) 5.80 0.010*
  Range 5–30 0–30 0–100 (2.76, 8.83)
 Average daily pain intensity VRS (±SD) 6.09 (±1.63) 4.89 (±2.34) 23.7 % (±28.40) 1.20 0.003*
  Range (VRS) 3–9 0–9 0–100 (0.43, 1.96)
 Average daily headache hours (±SD) 15.10 (±4.15) 12.44 (±6.18) 24.5 % (±34.24) 2.75 0.003*
  Range (hours) 2.0–24.0 0–24.0 0–100 (0.99, 4.50)
 Mean Patient estimated benefit (±SD)   30.0 % (±29.77)    
  Range   0–95    
Multiple headache phenotypes (n = 18)
 Headache daysa (±SD) 30.00 (±0.0) 19.39 (±11.80) 35.3 % (±39.37) 10.61 0.001
  Range 30 0–30 0–100 (4.73, 16.48)
 Moderate-to-severe headache daysa (±SD) 25.94 (±5.90) 13.78 (±13.97) 58.7 % (±45.48) 12.16 < 0.001
  Range 10–30 0–30 0–100 (6.63, 17.69)
 Average daily pain intensity VRS (±SD) 5.83 (±1.88) 4.22 (±3.04) 23.7 % (±28.40) 1.61 0.039
  Range (VRS) 3–9 0–10 0–100 (0.09, 3.12)
 Average daily headache hours (±SD) 17.72 (±6.96) 9.80 (±8.53) 45.4 % (±39.56) 7.91 0.001
  Range (hours) 5.0–24.0 0.0–24.0 0–100 (3.62, 12.21)
 Mean Patient estimated benefit (±SD)   35.2 % (±39.53)    
  Range   0–100    
  1. CI confidence interval, ONS occipital nerve stimulation, SD standard deviation, VRS verbal rating scale
  2. *P value less than 0.05; atime period one month