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Table 4 Grand-average somatosensory evoked potentials (SSEPs) latencies and amplitudes in healthy volunteers (HV), in the total group of migraine patients (M-tot) and its subgroups undergoing normo- (M-norm) or hypo- (M-hypo) caloric ketogenic diet (KD) before and after 1-month KD

From: Cortical functional correlates of responsiveness to short-lasting preventive intervention with ketogenic diet in migraine: a multimodal evoked potentials study

Electrophysiological parameters

HV (n = 18)

M-tot (n = 18)

 

M-norm (n = 8)

 

M-hypo (n = 10)

 
  

Before

After

Before

After

Before

After

N9 (ms)

9.7 ± 0.7

9.8 ± 0.9

9.8 ± 0.7

9.5 ± 0.7

9.5 ± 0.7

10.0 ± 1.0

10.1 ± 0.5

N13 (ms)

13.4 ± 0.8

13.4 ± 1.0

13.3 ± 1.0

13.0 ± 0.7

13.0 ± 0.9

13.6 ± 1.1

13.6 ± 1.0

N20 (ms)

19.4 ± 1.2

19.1 ± 1.3

19.1 ± 1.2

18.4 ± 0.7

18.7 ± 0.8

19.7 ± 1.4

19.5 ± 1.4

P25 (ms)

24.9 ± 2.1

24.9 ± 3.1

25.7 ± 3.1

24.3 ± 2.2

25.1 ± 2.3

25.4 ± 3.7

26.1 ± 3.7

N33 (ms)

30.6 ± 2.4

31.5 ± 2.3

31.4 ± 3.1

31.2 ± 1.9

31.3 ± 3.1

31.8 ± 2.6

31.5 ± 3.3

N9-p (μV)

2.9 ± 1.4

3.0 ± 1.8

3.1 ± 2.0

3.3 ± 2.3

3.7 ± 2.3

2.7 ± 1.4

2.6 ± 1.6

N13-p (μV)

1.6 ± 0.5

1.6 ± 0.5

1.7 ± 0.5

1.8 ± 0.6

2.1 ± 0.4

1.4 ± 0.5

1.4 ± 0.4

N20-P25 (μV)

1.8 ± 0.6

1.8 ± 0.7

1.8 ± 0.9

1.8 ± 0.8

1.9 ± 1.1

1.8 ± 0.5

1.7 ± 0.6

P25-N33 (μV)

0.8 ± 0.4

0.9 ± 0.5

0.9 ± 0.4

1.0 ± 0.7

0.9 ± 0.2

0.9 ± 0.3

1.0 ± 0.5

N20-P25 1st amplitude (μV)

2.3 ± 0.9

2.1 ± 0.9

2.1 ± 1.2

2.2 ± 1.2

2.6 ± 1.5

2.0 ± 0.6

1.7 ± 0.8

N20-P25 amplitude slope

- 0.3 ± 0.7

0.3 ± 0.7 §

- 0.5 ± 0.6 *

0.4 ± 0.5

- 0.7 ± 0.7 *

0.2 ± 0.9

- 0.3 ± 0.4 *

  1. Data are expressed as means ± SD. * = p < 0.01 paired sample t test before vs. after 1-month ketogenic diet. § = p < 0.01 ANOVA vs. HV