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Table 3 Human studies of MSG which were referenced by ICHD-III beta

From: Does monosodium glutamate really cause headache? : a systematic review of human studies

First author study type Number of subjects MSG administration with (w) or without(w/o) food Statistical analysis in the paper statistical difference
Tarasoff L (1993) [6] human study 71 capsule w performed No difference
3.15 g MSG/300 ml soft drink w performed No difference
Yang WH (1997) [12] human study 61(self-identified MSG sensitive) 5 g MSG/200 ml strongly citrus-tasting beverage w/o performed No difference
36(self-identified MSG sensitive) 1.25–5 g MSG/200 ml strongly citrus-tasting beverage w/o performed 2.5, 5 g: Significant difference
Gore M (1980) [16] human study 55 1.5–6 g MSG/150 ml tap water w/o not performed No difference (Fisher test)
Kenny RA (1972) [17] human study 77 5 g MSG/150 ml tomato juice w/o not performed No difference (Fisher test)
22 1–5 g MSG/ 150 ml tomato juice or water w/o not performed cannot analyze
Merrit JE (1990) [18] in vitro