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Table 3 Human studies of MSG which were referenced by ICHD-III beta

From: Does monosodium glutamate really cause headache? : a systematic review of human studies

First author

study type

Number of subjects

MSG administration

with (w) or without(w/o) food

Statistical analysis in the paper

statistical difference

Tarasoff L (1993) [6]

human study

71

capsule

w

performed

No difference

3.15 g MSG/300 ml soft drink

w

performed

No difference

Yang WH (1997) [12]

human study

61(self-identified MSG sensitive)

5 g MSG/200 ml strongly citrus-tasting beverage

w/o

performed

No difference

36(self-identified MSG sensitive)

1.25–5 g MSG/200 ml strongly citrus-tasting beverage

w/o

performed

2.5, 5 g: Significant difference

Gore M (1980) [16]

human study

55

1.5–6 g MSG/150 ml tap water

w/o

not performed

No difference (Fisher test)

Kenny RA (1972) [17]

human study

77

5 g MSG/150 ml tomato juice

w/o

not performed

No difference (Fisher test)

22

1–5 g MSG/ 150 ml tomato juice or water

w/o

not performed

cannot analyze

Merrit JE (1990) [18]

in vitro