Cost-effectiveness analysis of non-invasive vagus nerve stimulation for the treatment of chronic cluster headache

Table 3 Parameters for the probabilistic sensitivity analysis

Parameter	Mean	SE	Distribution
Probability of response with nVNS + SoC	0.489	0.074	Beta
Probability of response with SoC alone	0.083	0.039	Beta
Probability of discontinued response	0.310	0.378	Normal^a
Utility score (nVNS + SoC responder)	0.772	NA	Multivariate normal
Utility score (nVNS + SoC non-responder)	0.536	NA	Multivariate normal
Utility score (SoC alone responder)	0.760	NA	Multivariate normal
Utility score (SoC alone non-responder)	0.523	NA	Multivariate normal
Resource use per 14 days
With nVNS + SoC
Zolmitriptan	1.6	0.82	Gamma
Sumatriptan	2.8	0.60	Gamma
Oxygen	6.5	1.65	Gamma
With SoC alone
Zolmitriptan	1.3	0.52	Gamma
Sumatriptan	7.5	1.38	Gamma
Oxygen	10.8	2.21	Gamma

Abbreviations: NA not applicable, nVNS non-invasive vagus nerve stimulation, SE standard error, SoC standard of care
^aBased on exponential survival function

ISSN: 1129-2377